Immune Responses in Rhinovirus-Induced Asthma Exacerbations

被引:31
|
作者
Steinke, John W. [1 ,3 ,4 ]
Borish, Larry [1 ,2 ,3 ,4 ]
机构
[1] Univ Virginia Hlth Syst, Dept Med, Charlottesville, VA 22908 USA
[2] Univ Virginia Hlth Syst, Dept Microbiol, Charlottesville, VA USA
[3] Univ Virginia Hlth Syst, Carter Immunol Ctr, Charlottesville, VA 22908 USA
[4] Univ Virginia Hlth Syst, Asthma & Allerg Dis Ctr, Charlottesville, VA 22908 USA
关键词
Rhinovirus; Asthma; Pathogenesis; Viral-induced asthma exacerbations; Innate immunity; Adaptive immunity; RESPIRATORY-TRACT INFECTIONS; AIRWAY EPITHELIAL-CELLS; RISK-FACTORS; IN-VIVO; HOSPITAL ADMISSIONS; VIRAL-INFECTIONS; VIRUS-INFECTION; COMMON COLD; CHILDREN; IGE;
D O I
10.1007/s11882-016-0661-2
中图分类号
R392 [医学免疫学];
学科分类号
100102 ;
摘要
Acute asthma exacerbations are responsible for urgent care visits and hospitalizations; they interfere with school and work productivity, thereby driving much of the morbidity and mortality associated with asthma. Approximately 80 to 85 % of asthma exacerbations in children, adolescents, and less frequently adults are associated with viral upper respiratory tract viral infections, and rhinovirus (RV) accounts for similar to 60-70 % of these virus-associated exacerbations. Evidence suggests that it is not the virus itself but the nature of the immune response to RV that drives this untoward response. In particular, evidence supports the concept that RV acts to exacerbate an ongoing allergic inflammatory response to environmental allergens present at the time of the infection. The interaction of the ongoing IgE-and T cell-mediated response to allergen superimposed on the innate and adaptive immune responses to the virus and how this leads to triggering of an asthma exacerbation is discussed.
引用
收藏
页数:8
相关论文
共 50 条
  • [41] Rhinovirus-induced CCL17 and CCL22 in Asthma Exacerbations and Differential Regulation by STAT6
    Williams, Teresa C.
    Jackson, David J.
    Maltby, Steven
    Walton, Ross P.
    Ching, Yee-Mann
    Glanville, Nicholas
    Singanayagam, Aran
    Brewins, Jennifer J.
    Clarke, Deborah
    Hirsman, Aurica G.
    Loo, Su-Ling
    Wei, Lan
    Beale, Janine E.
    Casolari, Paolo
    Caramori, Gaetano
    Papi, Alberto
    Belvisi, Maria
    Wark, Peter A. B.
    Johnston, Sebastian L.
    Edwards, Michael R.
    Bartlett, Nathan W.
    AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY, 2021, 64 (03) : 344 - 356
  • [42] FOXO3a regulates rhinovirus-induced innate immune responses in airway epithelial cells
    Gimenes-Junior, Joao
    Owuar, Nicole
    Vari, Hymavathi Reddy
    Li, Wuyan
    Xander, Nathaniel
    Kotnala, Sudhir
    Sajjan, Uma S.
    SCIENTIFIC REPORTS, 2019, 9 (1)
  • [43] Molecular profiling of bronchial biopsies in COPD during experimental rhinovirus-induced exacerbations
    Li, K.
    Mallia, P.
    Loza, M. J.
    Horowitz, D.
    Johnston, S. L.
    Baribaud, F.
    AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2010, 181
  • [44] FOXO3a regulates rhinovirus-induced innate immune responses in airway epithelial cells
    Joao Gimenes-Junior
    Nicole Owuar
    Hymavathi Reddy Vari
    Wuyan Li
    Nathaniel Xander
    Sudhir Kotnala
    Uma S. Sajjan
    Scientific Reports, 9
  • [45] Antibody responses to rhinovirus and echovirus antigens in children with asthma exacerbations
    Iwasaki, Jua
    Chai, Lee Ying
    Khoo, Siew-Kim
    Bizzintino, Joelene
    Laing, Ingrid A.
    Le Souef, Peter N.
    Thomas, Wayne R.
    Hales, Belinda J.
    EUROPEAN RESPIRATORY JOURNAL, 2015, 46
  • [46] Immune responses and exacerbations in severe asthma
    Camiolo, Matthew J.
    Kale, Sagar L.
    Oriss, Timothy B.
    Gauthier, Marc
    Ray, Anuradha
    CURRENT OPINION IN IMMUNOLOGY, 2021, 72 : 66 - 74
  • [47] Role Of Interleukine-33 In Rhinovirus-Induced Allergic Asthma Exacerbation
    Toussaint, Marie
    Singanayagam, Aran
    Johnston, Sebastian L.
    Bartlett, Nathan
    JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2014, 133 (02) : AB52 - AB52
  • [48] Rhinovirus-induced cytokine production of circulating leukocytes is reduced in severe asthma
    Jameel, Kaschin Jamal
    Yanik, Sarah
    Buelthoff, Eike
    Yusuf, Faisal
    Struck, Birte
    Rohde, Simon
    Pfeifer, Kai
    Kronsbein, Juliane
    Koch, Andrea
    Tenbusch, Matthias
    Knobloch, Juergen
    EUROPEAN RESPIRATORY JOURNAL, 2020, 56
  • [49] IL10 polymorphisms, rhinovirus-induced bronchiolitis, and childhood asthma
    Koponen, Petri
    Karjalainen, Minna K.
    Korppi, Matti
    JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2013, 131 (01) : 249 - 250
  • [50] Rhinovirus-induced wheezing in infancy-the first sign of childhood asthma?
    Kotaniemi-Syrjänen, A
    Vainionpää, R
    Reijonen, TM
    Waris, M
    Korhonen, K
    Korppi, M
    JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2003, 111 (01) : 66 - 71