Immune Responses in Rhinovirus-Induced Asthma Exacerbations

被引:31
|
作者
Steinke, John W. [1 ,3 ,4 ]
Borish, Larry [1 ,2 ,3 ,4 ]
机构
[1] Univ Virginia Hlth Syst, Dept Med, Charlottesville, VA 22908 USA
[2] Univ Virginia Hlth Syst, Dept Microbiol, Charlottesville, VA USA
[3] Univ Virginia Hlth Syst, Carter Immunol Ctr, Charlottesville, VA 22908 USA
[4] Univ Virginia Hlth Syst, Asthma & Allerg Dis Ctr, Charlottesville, VA 22908 USA
关键词
Rhinovirus; Asthma; Pathogenesis; Viral-induced asthma exacerbations; Innate immunity; Adaptive immunity; RESPIRATORY-TRACT INFECTIONS; AIRWAY EPITHELIAL-CELLS; RISK-FACTORS; IN-VIVO; HOSPITAL ADMISSIONS; VIRAL-INFECTIONS; VIRUS-INFECTION; COMMON COLD; CHILDREN; IGE;
D O I
10.1007/s11882-016-0661-2
中图分类号
R392 [医学免疫学];
学科分类号
100102 ;
摘要
Acute asthma exacerbations are responsible for urgent care visits and hospitalizations; they interfere with school and work productivity, thereby driving much of the morbidity and mortality associated with asthma. Approximately 80 to 85 % of asthma exacerbations in children, adolescents, and less frequently adults are associated with viral upper respiratory tract viral infections, and rhinovirus (RV) accounts for similar to 60-70 % of these virus-associated exacerbations. Evidence suggests that it is not the virus itself but the nature of the immune response to RV that drives this untoward response. In particular, evidence supports the concept that RV acts to exacerbate an ongoing allergic inflammatory response to environmental allergens present at the time of the infection. The interaction of the ongoing IgE-and T cell-mediated response to allergen superimposed on the innate and adaptive immune responses to the virus and how this leads to triggering of an asthma exacerbation is discussed.
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收藏
页数:8
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