Prognostic factors in endometrial carcinoma

被引:73
作者
Uharcek, Peter [1 ]
机构
[1] Fac Hosp, Dept Obstet & Gynecol, Nitra 94901, Slovakia
关键词
clinicopathological factors; endometrial carcinoma; prognosis;
D O I
10.1111/j.1447-0756.2008.00796.x
中图分类号
R71 [妇产科学];
学科分类号
100211 ;
摘要
Endometrial carcinoma is the most common malignancy of the female genital tract in industrialized countries, and occurs predominantly after the menopause. Although most endometrial carcinomas are detected at low stage, there is still a significant mortality from the disease. In postmenopausal women, prolonged life expectancy, changes in reproductive behavior and prevalence of overweight and obesity, as well as hormone replacement therapy use, may partially account for the observed increases of incidence rates in some countries. In order to improve treatment and follow-up of endometrial carcinoma patients, the importance of various prognostic factors has been extensively studied. The identification of high-risk groups would make it possible to avoid unnecessary adjuvant treatment among patients with a good prognosis. Over the past few decades, several studies have demonstrated the prognostic importance of different parameters including lymph node status, histological type of carcinoma (serous carcinoma and clear cell carcinomas are poor prognostic types), histological grade, stage of disease, depth of myometrial invasion, lymphovascular space involvement and cervical involvement. Other factors currently being investigated are estrogen and progesterone receptor status, p53 status, flow cytometric analysis for ploidy and S-phase fraction, and oncogenes such as HER-2/neu (c-erbB-2).
引用
收藏
页码:776 / 783
页数:8
相关论文
共 87 条
  • [1] ABELER VM, 1991, CANCER, V67, P3093, DOI 10.1002/1097-0142(19910615)67:12<3093::AID-CNCR2820671226>3.0.CO
  • [2] 2-L
  • [3] ABELER VM, 1992, CANCER, V69, P488, DOI 10.1002/1097-0142(19920115)69:2<488::AID-CNCR2820690236>3.0.CO
  • [4] 2-O
  • [5] ANGIOGENESIS IN ENDOMETRIAL HYPERPLASIA AND STAGE-I ENDOMETRIAL CARCINOMA
    ABULAFIA, O
    TRIEST, WE
    SHERER, DM
    HANSEN, CC
    GHEZZI, F
    [J]. OBSTETRICS AND GYNECOLOGY, 1995, 86 (04) : 479 - 485
  • [6] Microsatellite instability in enclometrioid type endometrial adenocarcinoma is associated with poor prognostic indicators
    An, Hee Jung
    Kim, Kivang Il
    Kim, Ji Young
    Shim, Jeong Youn
    Kang, Haeyoun
    Kim, Tae Heon
    Kim, Jin Kyung
    Jeong, Jeongmi Kim
    Lee, Sun Young
    Kim, Seung Jo
    [J]. AMERICAN JOURNAL OF SURGICAL PATHOLOGY, 2007, 31 (06) : 846 - 853
  • [7] Stage III endometrial cancer: Analysis of prognostic factors and failure patterns after adjuvant chemotherapy
    Aoki, Y
    Kase, H
    Watanabe, M
    Sato, T
    Kurata, H
    Tanaka, K
    [J]. GYNECOLOGIC ONCOLOGY, 2001, 83 (01) : 1 - 5
  • [8] Outcome of endometrial carcinoma patients with involvement of the uterine serosa
    Ashman, JB
    Connell, PP
    Yamada, D
    Rotmensch, J
    Waggoner, SE
    Mundt, AJ
    [J]. GYNECOLOGIC ONCOLOGY, 2001, 82 (02) : 338 - 343
  • [9] The prognostic value of PTEN, p53, and beta-catenin in endometrial carcinoma: a prospective immunocytochemical study
    Athanassiadou, P.
    Athanassiades, P.
    Grapsa, D.
    Gonidi, M.
    Athanassiadou, A. M.
    Stamati, P. N.
    Patsouris, E.
    [J]. INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER, 2007, 17 (03) : 697 - 704
  • [10] Immunohistochemically detected HER-2/neu-expression and prognosis in endometrial carcinoma
    Backe, J
    Gassel, AM
    Krebs, S
    Muller, T
    Caffier, H
    [J]. ARCHIVES OF GYNECOLOGY AND OBSTETRICS, 1997, 259 (04) : 189 - 195