Intramolecular Olefin Diamination for the Stereoselective Synthesis of 3-Aminopiperidines

被引：26
作者：
Kong, Aidi [1 ]
Blakey, Simon B. [1 ]
机构：
[1] Emory Univ, Dept Chem, Atlanta, GA 30322 USA
来源：
SYNTHESIS-STUTTGART | 2012年 / 44卷 / 08期
基金：
美国国家科学基金会;
关键词：
diamination; hypervalent iodine; oxidation; catalysis; piperidine; PALLADIUM-CATALYZED DIAMINATION; PHARMACOPHORE-BASED MOLECULES; INTEGRIN-ALPHA(V)BETA(3) ANTAGONISTS; ASYMMETRIC DIAMINATION; CONJUGATED DIENES; ALKENES; (-)-SLAFRAMINE; AMINOOXYGENATION; INDOLIZIDINES; SLAFRAMINE;
D O I：
10.1055/s-0031-1290591
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A general method for the direct intramolecular diamination of terminal olefins is presented. The reaction, mediated by hypervalent iodine oxidants, produces substituted 3-aminopiperidine scaffolds with high regio- and stereoselectivity, rendering this process relevant to both medicinal chemistry and natural products synthesis.
引用
收藏
页码：1190 / 1198
页数：9
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