Highly selective C-H bond activation of N-arylbenzimidamide and divergent couplings with diazophosphonate compounds: a catalyst-controlled selective synthetic strategy for 3-phosphorylindoles and 4-phosphorylisoquinolines

被引：38

作者：

Yang, Qiaolan ^{[1
,2
,3
]}

Wu, Chenglin ^{[2
,3
]}

Zhou, Jianhui ^{[2
,3
]}

He, Guoxue ^{[2
,3
]}

Liu, Hong ^{[2
,3
]}

Zhou, Yu ^{[2
,3
]}

机构：

[1] Univ Sci & Technol China, Nano Sci & Technol Inst, 166 Ren Ai Rd, Suzhou 215123, Peoples R China

[2] Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, 555 Zu Chong Zhi Rd, Shanghai 201203, Peoples R China

[3] Chinese Acad Sci, Shanghai Inst Mat Med, Key Lab Receptor Res, 555 Zu Chong Zhi Rd, Shanghai 201203, Peoples R China

来源：

ORGANIC CHEMISTRY FRONTIERS | 2019年 / 6卷 / 03期

基金：

中国国家自然科学基金;

关键词：

ARYL-PHOSPHO-INDOLE; DIAZO-COMPOUNDS; RH(III)-CATALYZED SYNTHESIS; PROPARGYL ALCOHOLS; PHOSPHORYLATION; CYCLIZATION; ANNULATION; ACID; ISOQUINOLINE; DERIVATIVES;

D O I：

10.1039/c8qo01148f

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A highly efficient synthetic strategy to construct 3-phosphorylindole and 4-phosphorylisoquinoline privileged scaffolds via selective C-H bond activations of N-phenylbenzimidamide and the subsequent divergent couplings with diazophosphonate compounds was achieved successfully by altering the Rh(III)/Ru(II) catalyst systems. This protocol features excellent chemoselectivity, wide substrate tolerance and mild reaction conditions, which might find wider application in the discovery of lead compounds in the future.

引用

页码：393 / 398

页数：6

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