A Highly Stereoselective Synthesis of E-(But-1-en-3-yne-1-sulfonyl) hetarenes and Disubstituted 2-Benzothiazolyl Alkynes by Palladium Catalyzed Sonogashira Type Coupling of 2-Chlorovinylsulfones

被引：3
作者：
Visnevska, Julija [1 ]
Belyakov, Sergey [1 ]
Abele, Edgars [1 ]
机构：
[1] Latvian Inst Organ Synth, LV-1006 Riga, Latvia
来源：
LETTERS IN ORGANIC CHEMISTRY | 2012年 / 9卷 / 04期
关键词：
Copper catalysis; E-2-chlorovinylsulfonylhetarenes; E-(but-1-en-3-yne-1-sulfonyl)hetarenes; Palladium catalysis; Sonogashira coupling; TERMINAL ALKYNES; ORGANIC HALIDES; EFFICIENT; ARYL; DERIVATIVES; ACETYLENES; SYSTEM; ACIDS;
D O I：
10.2174/157017812800233769
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Novel and highly stereoselective route to E-(but-1-en-3-yne-1-sulfonyl)hetarenes by palladium catalyzed Sonogashira type coupling of unstable E-2-chlorovinylsulfonylbenzene and E-2-(2-chlorovinylsulfonyl)pyridine was presented. Usage of potassium phosphate as novel base in Sonogashira reaction was demonstrated. Unusual coupling products in the Sonogashira reaction of E-2-(2-chlorovinylsulfanyl)benzothiazole with different alkynes were obtained.
引用
收藏
页码：250 / 256
页数：7
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