Current Advances in Aptamers for Cancer Diagnosis and Therapy

被引：129

作者：

Hori, Shin-ichiro ^{[1
,2
]}

Herrera, Alberto ^{[1
,3
]}

Rossi, John J. ^{[1
,3
]}

Zhou, Jiehua ^{[1
]}

机构：

[1] Beckman Res Inst City Hope, Dept Mol & Cellular Biol, 1500 E Duarte Rd, Duarte, CA 91010 USA

[2] Shionogi & Co Ltd, Drug Discovery & Dis Res Lab, 3-1-1 Futaba Cho, Toyonaka, Osaka 5610825, Japan

[3] Beckman Res Inst City Hope, Irell & Manella Grad Sch Biol Sci, 1500 E Duarte Rd, Duarte, CA 91010 USA

来源：

CANCERS | 2018年 / 10卷 / 01期

基金：

美国国家卫生研究院;

关键词：

cell-specific aptamer; SELEX; cancer diagnosis; cancer therapy; targeted delivery; HUMAN BREAST-CANCER; TARGETED DRUG-DELIVERY; MEMBRANE ANTIGEN PSMA; IN-VITRO SELECTION; FREE ELECTROCHEMICAL DETECTION; CONTROLLED-RELEASE DELIVERY; PROSTATE-SPECIFIC ANTIGEN; CELL LUNG-CANCER; LABEL-FREE; TUMOR-MARKER;

D O I：

10.3390/cancers10010009

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Nucleic acid aptamers are single-stranded oligonucleotides that interact with target molecules with high affinity and specificity in unique three-dimensional structures. Aptamers are generally isolated by a simple selection process called systematic evolution of ligands by exponential enrichment (SELEX) and then can be chemically synthesized and modified. Because of their high affinity and specificity, aptamers are promising agents for biomarker discovery, as well as cancer diagnosis and therapy. In this review, we present recent progress and challenges in aptamer and SELEX technology and highlight some representative applications of aptamers in cancer therapy.

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