microRNA based prognostic biomarkers in pancreatic Cancer

被引：42
作者：
Guo, Shixiang [1 ,2 ]
Fesler, Andrew [1 ]
Wang, Huaizhi [2 ]
Ju, Jingfang [1 ]
机构：
[1] SUNY Stony Brook, Stony Brook, NY 11794 USA
[2] Third Mil Med Univ, Chongqing 400038, Peoples R China
来源：
BIOMARKER RESEARCH | 2018年 / 6卷
基金：
中国国家自然科学基金;
关键词：
Pancreatic ductal adenocarcinoma; miRNA; Biomarkers; Resistance; Prognosis; Chemotherapy; Gemcitabine; PHASE-III TRIAL; MESENCHYMAL TRANSITION; DUCTAL ADENOCARCINOMA; NONCODING RNAS; GEMCITABINE; EXPRESSION; COMBINATION; PROGRESSION; MECHANISM; APOPTOSIS;
D O I：
10.1186/s40364-018-0131-1
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Despite tremendous research efforts focused on diagnosis and treatment, pancreatic ductal adenocarcinoma remains the third leading cause of cancer-related death in the United States, with a 5-year overall survival rate of less than 5%. Although resistance is rather complex, emerging evidence has demonstrated that epigenetic alterations (e.g. miRNA) have important roles in PDAC progression as well as resistance to therapy. Certain miRNAs have been identified as potential prognostic biomarkers in PDAC. In this review, we summarize the recent developments in miRNA research related to PDAC therapeutic resistance mechanisms and the potential of miRNAs as prognostic biomarkers for future clinical management of PDAC.
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页数：5
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