A concise procedure for the preparation of enantiopure 3-alkylpiperidines

被引：25

作者：

Amat, M

Llor, N

Hidalgo, J

Bosch, J

机构：

[1] Laboratory of Organic Chemistry, Faculty of Pharmacy, University of Barcelona

来源：

TETRAHEDRON-ASYMMETRY | 1997年 / 8卷 / 13期

关键词：

D O I：

10.1016/S0957-4166(97)00204-8

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Reaction of (R)-phenylglycinol with racemic methyl 4-formylhexanoate takes place with a remarkable stereoselectivity to give two diastereomeric 6-ethyloxazolopiperidones (9:1 ratio) in 76% overall yield. After LiAlH4 reduction and catalytic hydrogenation, the major isomer was converted to (S)-3-ethylpiperidine. (C) 1997 Elsevier Science Ltd.

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页码：2237 / 2240

页数：4

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