Rhodium catalyzed cyanide-free cyanation of aryl halide by using formamide as a cyanide source

被引：32

作者：

Khemnar, Ashok B. ^{[1
]}

Sawant, Dinesh N. ^{[1
]}

Bhanage, Bhalchandra M. ^{[1
]}

机构：

[1] Inst Chem Technol, Dept Chem, Bombay 400019, Maharashtra, India

来源：

TETRAHEDRON LETTERS | 2013年 / 54卷 / 21期

关键词：

Aryl halides; Cyanation; Formamide; Rhodium; Xantphos; PALLADIUM; BROMIDES; NITRILES; CHLORIDES; MILD; N; N-DIMETHYLFORMAMIDE; TRANSFORMATION; HALOGEN; IODIDES; COMPLEX;

D O I：

10.1016/j.tetlet.2013.03.052

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

This work reports rhodium-xantphos as a new catalytic system for cyanide-free cyanation of aryl halides to aryl nitriles. The reaction takes place in the presence of phosphorous oxychloride as an acid and formamide as a cyanide source cum solvent. The developed protocol avoids the use of highly toxic metal cyanides. This methodology is a simple, single step reaction involving formamide as a safe and nontoxic source of cyanation. A variety of aryl iodides/bromides were well tolerated under optimized reaction conditions providing moderate to excellent yield of corresponding cyanides. (c) 2013 Elsevier Ltd. All rights reserved.

引用

页码：2682 / 2684

页数：3

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