Palladium-catalyzed oxidative cyclization of N-aryl enamines:: From anilines to indoles

被引：415

作者：

Wuertz, Sebastian ^{[1
]}

Rakshit, Souvik ^{[1
]}

Neumann, Julia J. ^{[1
]}

Droege, Thomas ^{[1
]}

Glorius, Frank ^{[1
]}

机构：

[1] Univ Munster, Inst Organ Chem, D-48149 Munster, Germany

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2008年 / 47卷 / 38期

关键词：

C-H activation; heterocycles; indoles; oxidation; palladium;

D O I：

10.1002/anie.200802482

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

(Chemical Equation Presented) The special advantage of the title reaction to form substituted indoles 2 lies within the broad scope of the transformation: A multitude of N-aryl enaminones 1 can be prepared readily in one step from commercially available anilines. Furthermore, anilines can be converted directly in a one-pot process into the indole products. R1 = H, Me, OMe, Cl, F, carbonyl functionality, CN, fused aryl; R2 = alkyl, aryl; R 3 = alkyl, O-alkyl. © 2008 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：7230 / 7233

页数：4

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