ANTIPROLIFERATIVE EFFECT OF VALPROIC ACID AND 5,7-DIMETHOXYCOUMARIN AGAINST A2058 HUMAN MELANOMA CELLS

被引：0
|
作者：
Wolny, Daniel [1 ]
Chodurek, Ewa [1 ]
Dzierzewicz, Zofia [1 ]
机构：
[1] Med Univ Silesia, Sch Pharm, Div Lab Med, Dept Biopharm, Jednosci 8 St, PL-41200 Sosnowiec, Poland
来源：
ACTA POLONIAE PHARMACEUTICA | 2014年 / 71卷 / 06期
关键词：
melanoma; A2058 human melanoma cells. valproic acid; 5,7-dimethoxycoumarin;
D O I：
暂无
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Melanoma is one of the most malignant tumors of a dangerous high incidence and high metastatic potential. It grows quickly and in an advanced stage is resistant to radio-. chemn- and immunotherapy, which makes it difficult to cure. Therefore, research efforts are focused on the development of new therapeutics or chemopreventive strategies. The aim of the study was to investigate whether the valproic acid and 5,7-dimethoxycoumarin have an antiproliferative activity against A2058 human melanoma cell line. Investigated compounds inhibited the proliferation of cells, however, no synergistic effect of their co-administration was observed.
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收藏
页码：1056 / 1059
页数：4
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