Biologically Active Peptides from Venoms: Applications in Antibiotic Resistance, Cancer, and Beyond

被引：18
作者：
Ageitos, Lucia [1 ,2 ,3 ,4 ,5 ,6 ]
Torres, Marcelo D. T. [1 ,2 ,3 ,4 ]
de la Fuente-nunez, Cesar [1 ,2 ,3 ,4 ]
机构：
[1] Univ Penn, Inst Biomed Informat, Inst Translat Med & Therapeut, Perelman Sch Med, Philadelphia, PA 19104 USA
[2] Univ Penn, Sch Engn & Appl Sci, Dept Bioengn, Philadelphia, PA 19104 USA
[3] Univ Penn, Chem & Biomol Engn, Philadelphia, PA 19104 USA
[4] Univ Penn, Chem & Biomol Engn, Philadelphia, PA 19104 USA
[5] Univ A Coruna, Ctr Interdisciplinar Quim & Biol CICA, Fac Ciencias, La Coruna 15071, Spain
[6] Univ A Coruna, Dept Quim, Fac Ciencias, La Coruna 15071, Spain
来源：
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2022年 / 23卷 / 23期
基金：
美国国家卫生研究院;
关键词：
antimicrobial peptides; venom; cancer; South America; neurotoxins; SERRULATUS SCORPION-VENOM; ANTIMICROBIAL PEPTIDES; TOXINS; CATHELICIDINS; NEUROTOXIN; CROTAMINE; BIOLOGY; FAMILY; TS2;
D O I：
10.3390/ijms232315437
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Peptides are potential therapeutic alternatives against global diseases, such as antimicrobial-resistant infections and cancer. Venoms are a rich source of bioactive peptides that have evolved over time to act on specific targets of the prey. Peptides are one of the main components responsible for the biological activity and toxicity of venoms. South American organisms such as scorpions, snakes, and spiders are important producers of a myriad of peptides with different biological activities. In this review, we report the main venom-derived peptide families produced from South American organisms and their corresponding activities and biological targets.
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页数：17
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