The immune system and postmenopausal osteoporosis

被引：33

作者：

D'Amelio, Patrizia ^{[1
]}

机构：

[1] Univ Turin, Dept Med Sci, Gerontol Sect, I-10126 Turin, Italy

来源：

IMMUNOLOGICAL INVESTIGATIONS | 2013年 / 42卷 / 07期

关键词：

B cells; cytokines; immune system; menopause; osteoclast; osteoporosis; T cells; KAPPA-B LIGAND; TUMOR-NECROSIS-FACTOR; INDUCED BONE LOSS; LOSS IN-VIVO; HORMONE REPLACEMENT THERAPY; MEMBRANE ESTROGEN-RECEPTORS; CLASS-II TRANSACTIVATOR; T-CELL-ACTIVATION; OSTEOCLAST FORMATION; TNF-ALPHA;

D O I：

10.3109/08820139.2013.822764

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

In the last decay investigators have paid attention to the relation between immune system, estrogen deficiency and bone loss; some of the pathways have been clarified whereas others remain an unexplained challenge. This review summarizes the evidence that links immune cells, estrogen loss, and osteoclast formation and activity.

引用

页码：544 / 554

页数：11

共 81 条

[21] Dickkopf-1 is a master regulator of joint remodeling [J].

Diarra, Danielle ;

Stolina, Marina ;

Polzer, Karin ;

Zwerina, Jochen ;

Ominsky, Michael S. ;

Dwyer, Denise ;

Korb, Adelheid ;

Smolen, Josef ;

Hoffmann, Markus ;

Scheinecker, Clemens ;

van der Heide, Desiree ;

Landewe, Robert ;

Lacey, Dave ;

Richards, William G. ;

Schett, Georg .

NATURE MEDICINE, 2007, 13 (02) :156-163

[22] Role of RANK ligand in mediating increased bone resorption in early postmenopausal women [J].

Eghbali-Fatourechi, G ;

Khosla, S ;

Sanyal, A ;

Boyle, WJ ;

Lacey, DL ;

Riggs, BL .

JOURNAL OF CLINICAL INVESTIGATION, 2003, 111 (08) :1221-1230

[23] T cells potentiate PTH-induced cortical bone loss through CD40L signaling [J].

Gao, Yuhao ;

Wu, Xiaojun ;

Terauchi, Masakazu ;

Li, Jau-Yi ;

Grassi, Francesco ;

Galley, Sarah ;

Yang, Xiaoying ;

Weitzmann, M. Neale ;

Pacifici, Roberto .

CELL METABOLISM, 2008, 8 (02) :132-145

[24] IFN-γ stimulates osteoclast formation and bone loss in vivo via antigen-driven T cell activation [J].

Gao, Yuhao ;

Grassi, Francesco ;

Ryan, Michaela Robbie ;

Terauchi, Masakazu ;

Page, Karen ;

Yang, Xiaoying ;

Weitzmann, M. Neale ;

Pacifici, Roberto .

JOURNAL OF CLINICAL INVESTIGATION, 2007, 117 (01) :122-132

[25] Human myeloma cells stimulate the receptor activator of nuclear factor-κB ligand (RANKL) in T lymphocytes:: a potential role in multiple myeloma bone disease [J].

Giuliani, N ;

Colla, S ;

Sala, R ;

Moroni, M ;

Lazzaretti, M ;

La Monica, S ;

Bonomini, S ;

Hojden, M ;

Sammarelli, G ;

Barillè, S ;

Bataille, R ;

Rizzoli, V .

BLOOD, 2002, 100 (13) :4615-4621

[26] Activated T lymphocytes suppress osteoclastogenesis by diverting early monocyte/macrophage progenitor lineage commitment towards dendritic cell differentiation through down-regulation of receptor activator of nuclear factor-kappaB and c-Fos [J].

Grcevic, D. ;

Lukic, I. K. ;

Kovacic, N. ;

Ivcevic, S. ;

Katavic, V. ;

Marusic, A. .

CLINICAL AND EXPERIMENTAL IMMUNOLOGY, 2006, 146 (01) :146-158

[27] The role of CD40 ligand in costimulation and T-cell activation [J].

Grewal, IS ;

Flavell, RA .

IMMUNOLOGICAL REVIEWS, 1996, 153 :85-106

[28] Expression of receptor activator of nuclear factor-κB ligand by B cells in response to oral bacteria [J].

Han, X. ;

Lin, X. ;

Seliger, A. R. ;

Eastcott, J. ;

Kawai, T. ;

Taubman, M. A. .

ORAL MICROBIOLOGY AND IMMUNOLOGY, 2009, 24 (03) :190-196

[29] Porphyromonas gingivalis Infection-Associated Periodontal Bone Resorption Is Dependent on Receptor Activator of NF-κB Ligand [J].

Han, Xiaozhe ;

Lin, Xiaoping ;

Yu, Xiaoqian ;

Lin, Jiang ;

Kawai, Toshihisa ;

LaRosa, Karen B. ;

Taubman, Martin A. .

INFECTION AND IMMUNITY, 2013, 81 (05) :1502-1509

[30]

Hofbauer L. C., 2004, Journal of Musculoskeletal & Neuronal Interactions, V4, P268

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