The immune system and postmenopausal osteoporosis

被引：33

作者：

D'Amelio, Patrizia ^{[1
]}

机构：

[1] Univ Turin, Dept Med Sci, Gerontol Sect, I-10126 Turin, Italy

来源：

IMMUNOLOGICAL INVESTIGATIONS | 2013年 / 42卷 / 07期

关键词：

B cells; cytokines; immune system; menopause; osteoclast; osteoporosis; T cells; KAPPA-B LIGAND; TUMOR-NECROSIS-FACTOR; INDUCED BONE LOSS; LOSS IN-VIVO; HORMONE REPLACEMENT THERAPY; MEMBRANE ESTROGEN-RECEPTORS; CLASS-II TRANSACTIVATOR; T-CELL-ACTIVATION; OSTEOCLAST FORMATION; TNF-ALPHA;

D O I：

10.3109/08820139.2013.822764

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

In the last decay investigators have paid attention to the relation between immune system, estrogen deficiency and bone loss; some of the pathways have been clarified whereas others remain an unexplained challenge. This review summarizes the evidence that links immune cells, estrogen loss, and osteoclast formation and activity.

引用

页码：544 / 554

页数：11

共 81 条

[1] Signaling regulation of genomic and nongenomic functions of estrogen receptors [J].

Acconcia, Filippo ;

Kumar, Rakesh .

CANCER LETTERS, 2006, 238 (01) :1-14

[2] IL-23 Is Critical for Induction of Arthritis, Osteoclast Formation, and Maintenance of Bone Mass [J].

Adamopoulos, Iannis E. ;

Tessmer, Marlowe ;

Chao, Cheng-Chi ;

Adda, Sarvesh ;

Gorman, Dan ;

Petro, Mary ;

Chou, Chuan-Chu ;

Pierce, Robert H. ;

Yao, Wei ;

Lane, Nancy E. ;

Laface, Drake ;

Bowman, Edward P. .

JOURNAL OF IMMUNOLOGY, 2011, 187 (02) :951-959

[3] 17β-estradiol inhibits class II major histocompatibility complex (MHC) expression:: Influence on histone modifications and CBP recruitment to the class II MHC promoter [J].

Adamski, J ;

Ma, ZD ;

Nozell, S ;

Benveniste, EN .

MOLECULAR ENDOCRINOLOGY, 2004, 18 (08) :1963-1974

[4] Risedronate reduces osteoclast precursors and cytokine production in postmenopausal osteoporotic women [J].

Amelio, Patrizia D. ;

Grimaldi, Anastasia ;

Di Bella, Stefania ;

Tamone, Cristina ;

Brianza, Stefano Z. M. ;

Ravazzoli, Marco G. A. ;

Bernabei, Paola ;

Cristofaro, Maria Angela ;

Pescarmona, Gian Piero ;

Isaia, Giancarlo .

JOURNAL OF BONE AND MINERAL RESEARCH, 2008, 23 (03) :373-379

[5] Lymphocytes and the Dap12 Adaptor Are Key Regulators of Osteoclast Activation Associated with Gonadal Failure [J].

Anginot, Adrienne ;

Dacquin, Romain ;

Mazzorana, Marlene ;

Jurdic, Pierre .

PLOS ONE, 2007, 2 (07)

[6]

Ascenzi Paolo, 2006, Molecular Aspects of Medicine, V27, P299, DOI 10.1016/j.mam.2006.07.001

[7] Inhibition of antigen presentation and T cell costimulation blocks PTH-induced bone loss [J].

Bedi, Brahmchetna ;

Li, Jau-Yi ;

Grassi, Francesco ;

Tawfeek, Hesham ;

Weitzmann, M. Neale ;

Pacifici, Roberto .

SKELETAL BIOLOGY AND MEDICINE, 2010, 1192 :215-221

[8] Tumor necrosis factorinhibiting therapy preferentially targets bone destruction but not synovial inflammation in a tumor necrosis factordriven model of rheumatoid arthritis [J].

Binder, Nikolaus B. ;

Puchner, Antonia ;

Niederreiter, Birgit ;

Hayer, Silvia ;

Leiss, Harald ;

Blueml, Stephan ;

Kreindl, Roman ;

Smolen, Josef S. ;

Redlich, Kurt .

ARTHRITIS AND RHEUMATISM, 2013, 65 (03) :608-617

[9] Estrogen deficiency induces bone loss by enhancing T-cell production of TNF-α [J].

Cenci, S ;

Weitzmann, MN ;

Roggia, C ;

Namba, N ;

Novack, D ;

Woodring, J ;

Pacifici, R .

JOURNAL OF CLINICAL INVESTIGATION, 2000, 106 (10) :1229-1237

[10] Estrogen deficiency induces bone loss by increasing T cell proliferation and lifespan through IFN-γ-induced class II transactivator [J].

Cenci, S ;

Toraldo, G ;

Weitzmann, MN ;

Roggia, C ;

Gao, YH ;

Qian, WP ;

Sierra, O ;

Pacifici, R .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2003, 100 (18) :10405-10410

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