Multidisciplinary Management of Locally Advanced Rectal Cancer: Neoadjuvant Approaches

被引：7

作者：

Murugappan, Swaminathan ^{[1
,2
,3
]}

Harris, William P. ^{[1
,2
,3
]}

Willett, Christopher G. ^{[4
]}

Lin, Edward ^{[1
,2
,3
]}

机构：

[1] Fred Hutchinson Canc Res Ctr, Seattle, WA 98104 USA

[2] Seattle Canc Care Alliance, Seattle, WA 98109 USA

[3] Univ Washington, Seattle, WA 98195 USA

[4] Duke Univ, Med Ctr, Div Radiat Oncol, Durham, NC 27710 USA

来源：

JOURNAL OF THE NATIONAL COMPREHENSIVE CANCER NETWORK | 2013年 / 11卷 / 05期

关键词：

TOTAL MESORECTAL EXCISION; PHASE-III TRIAL; PREOPERATIVE RADIOTHERAPY; POSTOPERATIVE CHEMORADIOTHERAPY; ADJUVANT THERAPY; PROGNOSTIC-SIGNIFICANCE; EUROPEAN ORGANIZATION; CLINICAL-SIGNIFICANCE; COLORECTAL-CANCER; RADIATION-THERAPY;

D O I：

10.6004/jnccn.2013.0071

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Although tumor biology and genomics of colon and rectal cancer are no different, patients with locally advanced rectal cancer (LARC) require neoadjuvant fluoropyrimidine-based chemoradiation and total mesorectal excision. In addition to known clinical risk factors, improved algorithms integrating molecular tools are needed to stratify patients with LARC to improve treatment outcomes and reduce acute and long-term toxicities. Simply combining newer systemic or targeted agents with standard treatment in all patients yielded little success but added toxicities. This article reviews the historical data, current standards of care, and ongoing research efforts regarding biomarkers, molecular imaging, and personalized genomic information.

引用

页码：548 / 557

页数：10

共 86 条

[31] Evaluation of a policy of total mesorectal excision for rectal and rectosigmoid cancers [J].

Hainsworth, PJ ;

Egan, MJ ;

Cunliffe, WJ .

BRITISH JOURNAL OF SURGERY, 1997, 84 (05) :652-656

[32]

HEALD RJ, 1986, LANCET, V1, P1479

[33] Phase I trial of cetuximab in combination with capecitabine, weekly irinotecan, and radiotherapy as neoadjuvant therapy for rectal cancer [J].

Hofheinz, Ralf-Dieter ;

Horisberger, Karoline ;

Woernle, Christoph ;

Wenz, Frederik ;

Kraus-Tiefenbacher, Uta ;

Kaehler, Georg ;

Dinter, Dietmar ;

Grobholz, Rainer ;

Heeger, Steffen ;

Post, Stefan ;

Hochhaus, Andreas ;

Willeke, Frank .

INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 2006, 66 (05) :1384-1390

[34] Chemoradiotherapy with capecitabine versus fluorouracil for locally advanced rectal cancer: a randomised, multicentre, non-inferiority, phase 3 trial [J].

Hofheinz, Ralf-Dieter ;

Wenz, Frederik ;

Post, Stefan ;

Matzdorff, Axel ;

Laechelt, Stephan ;

Hartmann, Joerg T. ;

Mueller, Lothar ;

Link, Hartmut ;

Moehler, Markus ;

Kettner, Erika ;

Fritz, Elisabeth ;

Hieber, Udo ;

Lindemann, Hans Walter ;

Grunewald, Martina ;

Kremers, Stephan ;

Constantin, Christian ;

Hipp, Matthias ;

Hartung, Gernot ;

Gencer, Deniz ;

Kienle, Peter ;

Burkholder, Iris ;

Hochhaus, Andreas .

LANCET ONCOLOGY, 2012, 13 (06) :579-588

[35] Clinical Significance of Circulating Tumor Cells, Including Cancer Stem-Like Cells, in Peripheral Blood for Recurrence and Prognosis in Patients With Dukes' Stage B and C Colorectal Cancer [J].

Iinuma, Hisae ;

Watanabe, Toshiaki ;

Mimori, Koshi ;

Adachi, Miki ;

Hayashi, Naoko ;

Tamura, Junko ;

Matsuda, Keiji ;

Fukushima, Ryoji ;

Okinaga, Kota ;

Sasako, Mitsuru ;

Mori, Masaki .

JOURNAL OF CLINICAL ONCOLOGY, 2011, 29 (12) :1547-1555

[36] Preoperative radiotherapy combined with total mesorectal excision for resectable rectal cancer [J].

Kapiteijn, E ;

Marijnen, CAM ;

Nagtegaal, ID ;

Putter, H ;

Steup, WH ;

Wiggers, T ;

Rutten, HJT ;

Pahlman, L ;

Glimelius, B ;

van Krieken, JHJM ;

Leer, JWH ;

van de Velde, CJH .

NEW ENGLAND JOURNAL OF MEDICINE, 2001, 345 (09) :638-646

[37] Clinical significance of radiation-induced CD133 expression in residual rectal cancer cells after chemoradiotherapy [J].

Kawamoto, Aya ;

Tanaka, Koji ;

Saigusa, Susumu ;

Toiyama, Yuji ;

Morimoto, Yuhki ;

Fujikawa, Hiroyuki ;

Iwata, Takashi ;

Matsushita, Kohei ;

Yokoe, Takeshi ;

Yasuda, Hiromi ;

Inoue, Yasuhiro ;

Miki, Chikao ;

Kusunoki, Masato .

EXPERIMENTAL AND THERAPEUTIC MEDICINE, 2012, 3 (03) :403-409

[38] Comparison of 5-fluorouracilaleucovorin and capecitabine in preoperative chemoradiotherapy for locally advanced rectal cancer [J].

Kim, Dae Yong ;

Jung, Kyung Hae ;

Kim, Tae Hyun ;

Kim, Duck-Woo ;

Chang, Hee Jin ;

Jeong, Jun Yong ;

Kim, Young Hoon ;

Son, Seok-Hyun ;

Yun, Tak ;

Hong, Chang Won ;

Sohn, Dae Kyung ;

Lim, Seok-Byung ;

Choi, Hyo Seong ;

Jeong, Seung-Yong ;

Park, Jae-Gahb .

INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 2007, 67 (02) :378-384

[39] KRAS Mutation Status and Clinical Outcome of Preoperative Chemoradiation With Cetuximab in Locally Advanced Rectal Cancer: A Pooled Analysis of 2 Phase II Trials [J].

Kim, Sun Young ;

Shim, Eun Kyung ;

Yeo, Hyun Yang ;

Baek, Ji Yeon ;

Hong, Yong Sang ;

Kim, Dae Yong ;

Kim, Tae Won ;

Kim, Jee Hyun ;

Im, Seock-Ah ;

Jung, Kyung Hae ;

Chang, Hee Jin .

INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 2013, 85 (01) :201-207

[40] Variable Clonal Repopulation Dynamics Influence Chemotherapy Response in Colorectal Cancer [J].

Kreso, Antonija ;

O'Brien, Catherine A. ;

van Galen, Peter ;

Gan, Olga I. ;

Notta, Faiyaz ;

Brown, Andrew M. K. ;

Ng, Karen ;

Ma, Jing ;

Wienholds, Erno ;

Dunant, Cyrille ;

Pollett, Aaron ;

Gallinger, Steven ;

McPherson, John ;

Mullighan, Charles G. ;

Shibata, Darryl ;

Dick, John E. .

SCIENCE, 2013, 339 (6119) :543-548

← 1 2 3 4 5 6 7 8 9 →