JNK signaling in apoptosis

被引：1279

作者：

Dhanasekaran, D. N. ^{[1
]}

Reddy, E. P. ^{[1
]}

机构：

[1] Temple Univ, Sch Med, Fels Inst Canc Res & Mol Biol, Philadelphia, PA 19140 USA

来源：

ONCOGENE | 2008年 / 27卷 / 48期

基金：

美国国家卫生研究院;

关键词：

JNK; apoptosis; cell death; MAP3K; MKK4; MKK7;

D O I：

10.1038/onc.2008.301

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Jun N-terminal kinases or JNKs play a critical role in death receptor-initiated extrinsic as well as mitochondrial intrinsic apoptotic pathways. JNKs activate apoptotic signaling by the upregulation of pro-apoptotic genes through the transactivation of specific transcription factors or by directly modulating the activities of mitochondrial pro-and antiapoptotic proteins through distinct phosphorylation events. This review analyses our present understanding of the role of JNK in apoptotic signaling and the various mechanisms by which JNK promotes apoptosis.

引用

页码：6245 / 6251

页数：7

共 73 条

[1] Direct activation of mitochondrial apoptosis machinery by c-Jun N-terminal kinase in adult cardiac myocytes [J].

Aoki, H ;

Kang, PM ;

Hampe, J ;

Yoshimura, K ;

Noma, T ;

Matsuzaki, M ;

Izumo, S .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2002, 277 (12) :10244-10250

[2] Pin1 promotes cell death in NGF-dependent neurons through a mechanism requiring c-Jun activity [J].

Barone, Maria Cecilia ;

Desouza, Lynette A. ;

Freeman, Robert S. .

JOURNAL OF NEUROCHEMISTRY, 2008, 106 (02) :734-745

[3] Amino-terminal phosphorylation of c-Jun regulates stress-induced apoptosis and cellular proliferation [J].

Behrens, A ;

Sibilia, M ;

Wagner, EF .

NATURE GENETICS, 1999, 21 (03) :326-329

[4] All JNKs can kill, but nuclear localization is critical for neuronal death [J].

Bjorkblom, Benny ;

Vainio, Jenni C. ;

Hongisto, Vesa ;

Herdegen, Thomas ;

Courtney, Michael J. ;

Coffey, Eleanor T. .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2008, 283 (28) :19704-19713

[5] Caspases induce cytochrome c release from mitochondria by activating cytosolic factors [J].

Bossy-Wetzel, E ;

Green, DR .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1999, 274 (25) :17484-17490

[6] PARALLEL SIGNAL-PROCESSING AMONG MAMMALIAN MAPKS [J].

CANO, E ;

MAHADEVAN, LC .

TRENDS IN BIOCHEMICAL SCIENCES, 1995, 20 (03) :117-122

[7] ANISOMYCIN-ACTIVATED PROTEIN KINASE-P45 AND KINASE-P55 BUT NOT MITOGEN-ACTIVATED PROTEIN KINASE-ERK-1 AND KINASE-ERK-2 ARE IMPLICATED IN THE INDUCTION OF C-FOS AND C-JUN [J].

CANO, E ;

HAZZALIN, CA ;

MAHADEVAN, LC .

MOLECULAR AND CELLULAR BIOLOGY, 1994, 14 (11) :7352-7362

[8] Mammalian MAP kinase signalling cascades [J].

Chang, LF ;

Karin, M .

NATURE, 2001, 410 (6824) :37-40

[9] JNK-dependent release of mitochondrial protein, Smac, during apoptosis in multiple myeloma (MM) cells [J].

Chauhan, D ;

Li, GL ;

Hideshima, T ;

Podar, K ;

Mitsiades, C ;

Mitsiades, N ;

Munshi, N ;

Kharbanda, S ;

Anderson, KC .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2003, 278 (20) :17593-17596

[10]

Chen YR, 2000, INT J ONCOL, V16, P651

← 1 2 3 4 5 6 7 8 →