Binuclear mercury(II) complexes of sulfonium ylides: Synthesis, structural characterization and anti-bacterial activity

被引：21

作者：

Sabounchei, Seyyed Javad ^{[1
]}

Bagherjeri, Fateme Akhlaghi ^{[1
]}

Boskovic, Colette ^{[2
]}

Gable, Robert W. ^{[2
]}

Karamian, Roya ^{[3
]}

Asadbegy, Mostafa ^{[3
]}

机构：

[1] Bu Ali Sina Univ, Fac Chem, Hamadan 65174, Iran

[2] Univ Melbourne, Sch Chem, Melbourne, Vic 3010, Australia

[3] Bu Ali Sina Univ, Fac Sci, Dept Biol, Hamadan 65174, Iran

来源：

JOURNAL OF MOLECULAR STRUCTURE | 2013年 / 1034卷

关键词：

Sulfonium ylide; Mercury(II) halide complex; X-ray crystal structure; Antibacterial effect; MOLECULAR-STRUCTURE; HALIDE-COMPLEXES; SULFUR YLIDE; RESISTANCE; CHEMISTRY;

D O I：

10.1016/j.molstruc.2012.10.051

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

Reaction of alpha-keto stabilized sulfonium ylides (Me)(2)SCHC(O)C6H4R (R = p-Me (a); p-Cl (b)) with HgX2 (X = Cl, Br and I) in equimolar ratios using methanol as solvent leads to binuclear products of the type [HgX2(ylide)](2) (X = Cl (1), Br (2) and I (3)). Single crystal X-ray diffraction analysis reveals the presence of unexpected asymmetric halide-bridged dinuclear structures for la and 2b. Characterization of the compounds by IR, H-1- and C-13 NMR spectroscopy confirmed coordination of the ylide to the metal through the carbon atom. In addition, the antibacterial effects of DMSO-solutions of the complexes were investigated by the disc diffusion method against three Gram positive and three negative bacteria. All complexes represent antibacterial activity against these bacteria with high levels of inhibitory potency exhibited against the Gram-positive species. (C) 2012 Elsevier B.V. All rights reserved.

引用

页码：265 / 270

页数：6

共 32 条

[1] Asymmetric sulfur ylide mediated aziridination: Application in the synthesis of the side chain of taxol [J].