Lipid Nanosystems in Topical PUVA Therapy

被引：4

作者：

Battaglia, Luigi ^{[1
]}

Peira, Elena ^{[1
]}

Sapino, Simona ^{[1
]}

Gallarate, Marina ^{[1
]}

机构：

[1] Univ Turin, Dipartimento Sci & Tecnol Farmaco, Turin, Italy

来源：

JOURNAL OF DISPERSION SCIENCE AND TECHNOLOGY | 2012年 / 33卷 / 04期

关键词：

Malondialdehyde MDA; psoralen; solid lipid nanoparticles (SLN); DELIVERY;

D O I：

10.1080/01932691.2011.567864

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

8-Methoxsalen was vehicled in nanoemulsion and in solid lipid nanoparticles (SLN) prepared by the hot homogenization technique in order to be used in topical psoralen UVA (PUVA) therapy. Drug entrapment efficiency in nanoparticles was improved by choosing the appropriate lipid matrix. The use of alpha-tocopherol in the lipid phase reduces 8-methoxsalen induced photooxidation of porcine skin, which was evaluated in vitro by a malondialdehyde (MDA) test: This result is promising to reduce in vivo human skin irritation after PUVA therapy, which can be attributed to skin photooxidation.

引用

收藏

页码：565 / 569

页数：5

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