Spiro Fused Diterpene-Indole Alkaloids from a Creek-Bottom-Derived Aspergillus terreus

被引：24

作者：

Cai, Shengxin

Du, Lin

Gerea, Alexandra L.

King, Jarrod B.

You, Jianlan

Cichewicz, Robert H. ^{[1
]}

机构：

[1] Univ Oklahoma, Stephenson Life Sci Res Ctr, Nat Prod Discovery Grp, Inst Nat Prod Applicat & Res Technol, Norman, OK 73019 USA

来源：

ORGANIC LETTERS | 2013年 / 15卷 / 16期

基金：

美国国家卫生研究院;

关键词：

METABOLITES; LEAVES; FUNGUS;

D O I：

10.1021/ol401891z

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Four metabolites, teraspiridoles A-D (2-5), formed from the merger of a diterpene and modified indole scaffold were obtained from an Aspergillus terreus isolate. The structures and absolute configurations of these natural products were established using NMR, mass spectrometry, Marfey's method, VCD, and ECD data. Teraspiridole B (3) exhibited weak inhibition of planaria regeneration/survival.

引用

页码：4186 / 4189

页数：4

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