Hypothyroidism in Pregnancy

被引:38
作者
Sullivan, Scott A. [1 ]
机构
[1] Med Univ South Carolina, Dept Obstet Gynecol, Div Maternal Fetal Med, Charleston, SC 29425 USA
关键词
hypothyroidism; pregnancy; hashimoto's thyroiditis; thyroid screening; subclinical hypothyroidism; MATERNAL THYROID-DEFICIENCY; SUBCLINICAL HYPOTHYROIDISM; 1ST TRIMESTER; STIMULATING HORMONE; TSH LEVELS; WOMEN; RISK; HYPOTHYROXINEMIA; CHILDHOOD; COMPLICATIONS;
D O I
10.1097/GRF.0000000000000432
中图分类号
R71 [妇产科学];
学科分类号
100211 ;
摘要
Hypothyroidism in pregnancy is defined as the presence of an elevated thyroid stimulating hormone during gestation, affecting 2% to 3% of the population. Overt hypothyroidism is diagnosed by a decreased FT4, while patients with a normal FT4 are considered to have subclinical disease. Poorly controlled disease is associated with both pregnancy complications and developmental delays in the offspring. Treatment consists of replacement with levothyroxine and regular monitoring. Most pregnant women will require an increase in their dosing from 25% to 30%. While treatment for SCH remains controversial, current recommendations do not support universal screening of low-risk women during pregnancy.
引用
收藏
页码:308 / 319
页数:12
相关论文
共 22 条
[1]   Overt and subclinical hypothyroidism complicating pregnancy [J].
Abalovich, M ;
Gutierrez, S ;
Alcaraz, G ;
Maccallini, G ;
Garcia, A ;
Levalle, O .
THYROID, 2002, 12 (01) :63-68
[2]   Timing and magnitude of increases in levothyroxine requirements during pregnancy in women with hypothyroidism [J].
Alexander, EK ;
Marqusee, E ;
Lawrence, J ;
Jarolim, P ;
Fischer, GA ;
Larsen, PR .
NEW ENGLAND JOURNAL OF MEDICINE, 2004, 351 (03) :241-249
[3]   2017 Guidelines of the American Thyroid Association for the Diagnosis and Management of Thyroid Disease During Pregnancy and the Postpartum [J].
Alexander, Erik K. ;
Pearce, Elizabeth N. ;
Brent, Gregory A. ;
Brown, Rosalind S. ;
Chen, Herbert ;
Dosiou, Chrysoula ;
Grobman, William A. ;
Laurberg, Peter ;
Lazarus, John H. ;
Mandel, Susan J. ;
Peeters, Robin P. ;
Sullivan, Scott .
THYROID, 2017, 27 (03) :315-+
[4]   Maternal thyroid deficiency and pregnancy complications: implications for population screening [J].
Allan, WC ;
Haddow, JE ;
Palomaki, GE ;
Williams, JR ;
Mitchell, ML ;
Hermos, RJ ;
Faix, JD ;
Klein, RZ .
JOURNAL OF MEDICAL SCREENING, 2000, 7 (03) :127-130
[5]   Thyroid stimulating hormone and free thyroxine in pregnancy: Expressing concentrations as multiples of the median (MoMs) [J].
Bestwick, Jonathan P. ;
John, Rhys ;
Maina, Aldo ;
Guaraldo, Varvara ;
Joomun, Mohammed ;
Wald, Nicholas J. ;
Lazarus, John H. .
CLINICA CHIMICA ACTA, 2014, 430 :33-37
[6]   Treatment of Subclinical Hypothyroidism or Hypothyroxinemia in Pregnancy [J].
Casey, B. M. ;
Thom, E. A. ;
Peaceman, A. M. ;
Varner, M. W. ;
Sorokin, Y. ;
Hirtz, D. G. ;
Reddy, U. M. ;
Wapner, R. J. ;
Thorp, J. M., Jr. ;
Saade, G. ;
Tita, A. T. N. ;
Rouse, D. J. ;
Sibai, B. ;
Iams, J. D. ;
Mercer, B. M. ;
Tolosa, J. ;
Caritis, S. N. ;
VanDorsten, J. P. .
NEW ENGLAND JOURNAL OF MEDICINE, 2017, 376 (09) :815-825
[7]   Perinatal significance of isolated maternal hypothyroxinemia identified in the first half of pregnancy [J].
Casey, Brian M. ;
Dashe, Jodi S. ;
Spong, Catherine Y. ;
McIntire, Donald D. ;
Leveno, Kenneth J. ;
Cunningham, Gary F. .
OBSTETRICS AND GYNECOLOGY, 2007, 109 (05) :1129-1135
[8]   Optimal management of hypothyroidism, hypothyroxinaemia and euthyroid TPO antibody positivity preconception and in pregnancy [J].
Chan, Shiao ;
Boelaert, Kristien .
CLINICAL ENDOCRINOLOGY, 2015, 82 (03) :313-326
[9]   RISK OF SUBCLINICAL HYPOTHYROIDISM IN PREGNANT-WOMEN WITH ASYMPTOMATIC AUTOIMMUNE THYROID-DISORDERS [J].
GLINOER, D ;
RIAHI, M ;
GRUN, JP ;
KINTHAERT, J .
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1994, 79 (01) :197-204
[10]   Maternal thyroid deficiency during pregnancy and subsequent neuropsychological development of the child [J].
Haddow, JE ;
Palomaki, GE ;
Allan, WC ;
Williams, JR ;
Knight, GJ ;
Gagnon, J ;
O'Heir, CE ;
Mitchell, ML ;
Hermos, RJ ;
Waisbren, SE ;
Faix, JD ;
Klein, RZ .
NEW ENGLAND JOURNAL OF MEDICINE, 1999, 341 (08) :549-555