Diacylglycerol Kinases: Regulated Controllers of T Cell Activation, Function, and Development

被引：31
作者：
Joshi, Rohan P. [1 ]
Koretzky, Gary A. [1 ,2 ]
机构：
[1] Univ Penn, Abramson Family Canc Res Inst, Philadelphia, PA 19104 USA
[2] Univ Penn, Perelman Sch Med, Dept Med, Philadelphia, PA 19104 USA
来源：
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2013年 / 14卷 / 04期
基金：
美国国家卫生研究院;
关键词：
diacylglycerol kinase; DGK; signal transduction; T cells; iNKT cells; anergy; tumor immunity; KAPPA-B ACTIVATION; PLECKSTRIN HOMOLOGY DOMAIN; PROTEIN-KINASE; RAS ACTIVATION; MOLECULAR-CLONING; PLASMA-MEMBRANE; FAS LIGAND; NUCLEAR-LOCALIZATION; INOSITOL PHOSPHATES; POSITIVE SELECTION;
D O I：
10.3390/ijms14046649
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Diacylglycerol kinases (DGKs) are a diverse family of enzymes that catalyze the conversion of diacylglycerol (DAG), a crucial second messenger of receptor-mediated signaling, to phosphatidic acid (PA). Both DAG and PA are bioactive molecules that regulate a wide set of intracellular signaling proteins involved in innate and adaptive immunity. Clear evidence points to a critical role for DGKs in modulating T cell activation, function, and development. More recently, studies have elucidated factors that control DGK function, suggesting an added complexity to how DGKs act during signaling. This review summarizes the available knowledge of the function and regulation of DGK isoforms in signal transduction with a particular focus on T lymphocytes.
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收藏
页码：6649 / 6673
页数：25
相关论文
共 121 条
[1]  
Abramovici H, 2003, MOL BIOL CELL, V14, P4499, DOI 10.1091/mbc.e03-03-0190
[2]   Morphological changes and spatial regulation of diacylglycerol kinase-ζ, syntrophins, and Rac1 during myoblast fusion [J].
Abramovici, Hanan ;
Gee, Stephen H. .
CELL MOTILITY AND THE CYTOSKELETON, 2007, 64 (07) :549-567
[3]   Diacylglycerol kinase α regulates the formation and polarisation of mature multivesicular bodies involved in the secretion of Fas ligand-containing exosomes in T lymphocytes [J].
Alonso, R. ;
Mazzeo, C. ;
Rodriguez, M. C. ;
Marsh, M. ;
Fraile-Ramos, A. ;
Calvo, V. ;
Avila-Flores, A. ;
Merida, I. ;
Izquierdo, M. .
CELL DEATH AND DIFFERENTIATION, 2011, 18 (07) :1161-1173
[4]   mTOR regulates memory CD8 T-cell differentiation [J].
Araki, Koichi ;
Turner, Alexandra P. ;
Shaffer, Virginia Oliva ;
Gangappa, Shivaprakash ;
Keller, Susanne A. ;
Bachmann, Martin F. ;
Larsen, Christian P. ;
Ahmed, Rafi .
NATURE, 2009, 460 (7251) :108-U124
[5]   Modulation of the mammalian target of rapamycin pathway by diacylglycerol kinase-produced phosphatidic acid [J].
Avila-Flores, A ;
Santos, T ;
Rincón, E ;
Mérida, I .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2005, 280 (11) :10091-10099
[6]   SAP-Mediated Inhibition of Diacylglycerol Kinase α Regulates TCR-Induced Diacylglycerol Signaling [J].
Baldanzi, Gianluca ;
Pighini, Andrea ;
Bettio, Valentina ;
Rainero, Elena ;
Traini, Sara ;
Chianale, Federica ;
Porporato, Paolo E. ;
Filigheddu, Nicoletta ;
Mesturini, Riccardo ;
Song, Shuping ;
Schweighoffer, Tamas ;
Patrussi, Laura ;
Baldari, Cosima T. ;
Zhong, Xiao-Ping ;
van Blitterswijk, Wim J. ;
Sinigaglia, Fabiola ;
Nichols, Kim E. ;
Rubio, Ignacio ;
Parolini, Ornella ;
Graziani, Andrea .
JOURNAL OF IMMUNOLOGY, 2011, 187 (11) :5941-5951
[7]   POSITIVE SELECTION OF MOUSE NK1(+) T-CELLS BY CD1-EXPRESSING CORTICAL THYMOCYTES [J].
BENDELAC, A .
JOURNAL OF EXPERIMENTAL MEDICINE, 1995, 182 (06) :2091-2096
[8]   The biology of NKT cells [J].
Bendelac, Albert ;
Savage, Paul B. ;
Teyton, Luc .
ANNUAL REVIEW OF IMMUNOLOGY, 2007, 25 :297-336
[9]   Molecular Origin and Functional Consequences of Digital Signaling and Hysteresis During Ras Activation in Lymphocytes [J].
Chakraborty, Arup K. ;
Das, Jayajit ;
Zikherman, Julie ;
Yang, Ming ;
Govern, Christopher C. ;
Ho, Mary ;
Weiss, Arthur ;
Roose, Jeroen .
SCIENCE SIGNALING, 2009, 2 (66) :pt2
[10]   Regulation and function of mTOR signalling in T cell fate decisions [J].
Chi, Hongbo .
NATURE REVIEWS IMMUNOLOGY, 2012, 12 (05) :325-338
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