Multicenter Study of Metastatic Lung Tumors Targeted by Interventional Cryoablation Evaluation (SOLSTICE)

被引：91

作者：

Callstrom, Matthew R. ^{[1
]}

Woodrum, David A. ^{[1
]}

Nichols, Francis C. ^{[2
]}

Palussiere, Jean ^{[3
]}

Buy, Xavier ^{[3
]}

Suh, Robert D. ^{[4
]}

Abtin, Fereidoun G. ^{[4
]}

Pua, Bradley B. ^{[5
]}

Madoff, David C. ^{[5
]}

Bagla, Sandeep L. ^{[6
]}

Papadouris, Dimitrios C. ^{[6
]}

Fernando, Hiran C. ^{[7
]}

Dupuy, Damian E. ^{[8
]}

Healey, Terrance T. ^{[8
]}

Moore, William H. ^{[9
,10
]}

Bilfinger, Thomas V. ^{[9
,10
]}

Solomon, Stephen B. ^{[11
]}

Yarmohammadi, Hooman ^{[11
]}

Krebs, Henry J. ^{[12
]}

Fulp, Charles J. ^{[12
]}

Hakime, Antoine ^{[13
]}

Tselikas, Lambros ^{[13
]}

de Baere, Thierry ^{[13
]}

机构：

[1] Mayo Clin, Dept Radiol, Rochester, MN 55902 USA

[2] Mayo Clin, Dept Surg, Rochester, MN USA

[3] Inst Bergonie, Dept Intervent Radiol, Bordeaux, France

[4] Ronald Reagan UCLA Med Ctr, Dept Radiol Sci, Los Angeles, CA USA

[5] New York Presbyterian Hosp, Weill Cornell Med Ctr, Dept Radiol, New York, NY USA

[6] Inova Alexandria Hosp, Cardiovasc & Intervent Radiol Dept, Alexandria, VA USA

[7] Inova Alexandria Hosp, Dept Surg, Alexandria, VA USA

[8] Brown Univ, Alpert Med Sch, Dept Diagnost Imaging, Providence, RI 02912 USA

[9] SUNY Stony Brook, Univ Hosp, Dept Radiol, Stony Brook, NY 11794 USA

[10] SUNY Stony Brook, Univ Hosp, Dept Surg, Stony Brook, NY 11794 USA

[11] Mem Sloan Kettering Canc Ctr, Dept Radiol, 1275 York Ave, New York, NY 10021 USA

[12] Canc Treatment Ctr Amer, Dept Radiol, Atlanta, GA USA

[13] Gustave Roussy, Dept Intervent Radiol, Canc Campus, Villejuif, France

来源：

JOURNAL OF THORACIC ONCOLOGY | 2020年 / 15卷 / 07期

关键词：

Lung metastasis; Cryoablation; Percutaneous ablation; Tumor efficacy; Safety; RADIOFREQUENCY ABLATION; PERCUTANEOUS CRYOABLATION; FEASIBILITY; CRYOTHERAPY; EXPERIENCE; EFFICACY; SAFETY; TRIAL;

D O I：

10.1016/j.jtho.2020.02.022

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Objective: To assess the safety and local recurrence-free survival in patients after cryoablation for treatment of pulmonary metastases. Methods: This multicenter, prospective, single-arm, phase 2 study included 128 patients with 224 lung metastases treated with percutaneous cryoablation, with 12 and 24 months of follow-up. The patients were enrolled on the basis of the outlined key inclusion criteria, which include one to six metastases from extrapulmonary cancers with a maximal diameter of 3.5 cm. Time to progression of the index tumor(s), metastatic disease, and overall survival rates were estimated using the Kaplan-Meier method. Complications were captured for 30 days after the procedure, and changes in performance status and quality of life were also evaluated. Results: Median size of metastases was 1.0 plus or minus 0.6 cm (0.2-4.5) with a median number of tumors of 1.0 plus or minus 1.2 cm (one to six). Local recurrence-free response (local tumor efficacy) of the treated tumor was 172 of 202 (85.1%) at 12 months and 139 of 180 (77.2%) at 24 months after the initial treatment. After a second cryoablation treatment for recurrent tumor, secondary local recurrence-free response (local tumor efficacy) was 184 of 202 (91.1%) at 12 months and 152 of 180 (84.4%) at 24 months. Kaplan-Meier estimates of 12- and 24-month overall survival rates were 97.6% (95% confidence interval: 92.6-99.2) and 86.6% (95% confidence interval: 78.7-91.7), respectively. Rate of pneumothorax that required pleural catheter placement was 26% (44/169). There were eight grade 3 complication events in 169 procedures (4.7%) and one (0.6%) grade 4 event. Conclusion: Percutaneous cryoablation is a safe and effective treatment for pulmonary metastases. (C) 2020 International Association for the Study of Lung Cancer. Published by Elsevier Inc. All rights reserved.

引用

页码：1200 / 1209

页数：10

共 22 条

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