Visceral analgesics: drugs with a great potential in functional disorders?

被引：19
作者：
Bradesi, Sylvie [1 ,2 ]
Herman, Jeremy [1 ]
Mayer, Emeran A. [1 ]
机构：
[1] Univ Calif Los Angeles, David Geffen Sch Med, Dept Med, Div Digest Dis,Ctr Neurobiol Stress, Los Angeles, CA 90073 USA
[2] VA Greater Los Angeles Healthcare Syst, CURE Digest Dis Res Ctr, Los Angeles, CA 90073 USA
来源：
CURRENT OPINION IN PHARMACOLOGY | 2008年 / 8卷 / 06期
关键词：
D O I：
10.1016/j.coph.2008.08.009
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Irritable bowel syndrome remains an incompletely understood, common syndrome with significant unmet medical needs. In IBS patients, abdominal pain is a primary factor related to quality of life impairment, symptom severity and health care utilization, and chronic visceral hyperalgesia has been identified as an important aspect of IBS pathophysiology. However, the development of therapies aimed at reducing this hyperalgesia (visceral analgesics) has been only partially successful despite preclinical evidence supporting the potential usefulness of several preclinical compounds aimed at peripheral as well as central targets.
引用
收藏
页码：697 / 703
页数：7
相关论文
共 68 条
[1]   PREDOMINANT SYMPTOMS IN IRRITABLE-BOWEL-SYNDROME CORRELATE WITH SPECIFIC AUTONOMIC NERVOUS-SYSTEM ABNORMALITIES [J].
AGGARWAL, A ;
CUTTS, TF ;
ABELL, TL ;
CARDOSO, S ;
FAMILONI, B ;
BREMER, J ;
KARAS, J .
GASTROENTEROLOGY, 1994, 106 (04) :945-950
[2]   Increased capsaicin receptor TRPV1-expressing sensory fibres in irritable bowel syndrome and their correlation with abdominal pain [J].
Akbar, A. ;
Yiangou, Y. ;
Facer, P. ;
Walters, J. R. F. ;
Anand, P. ;
Ghosh, S. .
GUT, 2008, 57 (07) :923-929
[3]   Effects of 5-hydroxytryptamine (serotonin) type 3 antagoniosts on symptom relief and constipation in nonconstipated irritable bowel syndrome: A systematic review and meta-analysis of randomized controlled trials [J].
Andresen, Viola ;
Montori, Victor M. ;
Keller, Jutta ;
West, Colin P. ;
Layer, Peter ;
Camilleri, Michael .
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY, 2008, 6 (05) :545-555
[4]   Duloxetine and other antidepressants in the treatment of patients with fibromyalgia [J].
Arnold, Lesley M. .
PAIN MEDICINE, 2007, 8 :S63-S74
[5]   Mechanisms of hypersensitivity in IBS and functional disorders [J].
Azpiroz, F. ;
Bouin, M. ;
Camilleri, M. ;
Mayer, E. A. ;
Poitras, P. ;
Serra, J. ;
Spiller, R. C. .
NEUROGASTROENTEROLOGY AND MOTILITY, 2007, 19 :62-88
[6]   Pregabalin pharmacology and its relevance to clinical practice [J].
Ben-Menachem, E .
EPILEPSIA, 2004, 45 :13-18
[7]   Capsaicin receptor (TRPV1) and non-erosive reflux disease [J].
Bhat, Yasser M. ;
Bielefeldt, Klaus .
EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY, 2006, 18 (03) :263-270
[8]  
Brandt LJ, 2002, AM J GASTROENTEROL, V97, pS7
[9]   Selective role for TRPV4 ion channels in visceral sensory pathways [J].
Brierley, Stuart M. ;
Page, Amanda J. ;
Hughes, Patrick A. ;
Adam, Birgit ;
Liebregts, Tobias ;
Cooper, Nicole J. ;
Holtmann, Gerald ;
Liedtke, Wolfgang ;
Blackshaw, L. Ashley .
GASTROENTEROLOGY, 2008, 134 (07) :2059-2069
[10]   A Randomized, Controlled Exploratory Study of Clonidine in Diarrhea-Predominant Irritable Bowel Syndrome [J].
Camilleri, Michael ;
Kim, Doe-Young ;
Mckinzie, Sanna ;
Kim, H. Jae ;
Thomforde, George M. ;
Burton, Duane D. ;
Low, Phillip A. ;
Zinsmeister, Alan R. .
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY, 2003, 1 (02) :111-121
1234567