Exocrine pancreatic insufficiency: prevalence, diagnosis, and management

被引：118
作者：
Capurso, Gabriele [1 ]
Traini, Mariaemilia [1 ]
Piciucchi, Matteo [2 ]
Signoretti, Marianna [2 ]
Arcidiacono, Paolo Giorgio [1 ]
机构：
[1] Univ Vita Salute San Raffaele, San Raffaele Sci Inst, Pancreas Translat & Clin Res Ctr, Pancreatobiliary Endoscopy & Endosonog Div, Milan, Italy
[2] Sapienza Univ, St Andrea Hosp, Digest & Liver Dis Unit, Rome, Italy
来源：
CLINICAL AND EXPERIMENTAL GASTROENTEROLOGY | 2019年 / 12卷
关键词：
exocrine pancreatic insufficiency; chronic pancreatitis; pancreatic cancer; elastase; malnutrition; diagnosis; therapy; ENZYME REPLACEMENT THERAPY; EVIDENCE-BASED GUIDELINES; FECAL ELASTASE-1; CYSTIC-FIBROSIS; SECRETIN STIMULATION; CONSENSUS GUIDELINES; FAT MALABSORPTION; CELIAC-DISEASE; CLINICAL-TRIAL; TEST MEALS;
D O I：
10.2147/CEG.S168266
中图分类号：
R57 [消化系及腹部疾病];
学科分类号：
摘要：
Exocrine pancreatic insufficiency (EPI) is a condition caused by reduced or inappropriate secretion or activity of pancreatic juice and its digestive enzymes, pancreatic lipase in particular. EPI can result in clinical manifestation and biochemical alterations causing reduced quality of life and life-threating complications. EPI is common in pancreatic disorders, where it should be suspected and actively investigated, and in many extrapancreatic conditions. There are various tests available to diagnose EPI, with indirect, noninvasive ones, such as concentration of fecal elastase being more commonly employed. Administration of pancreatic enzymes replacement therapy remains the mainstay of EPI treatment. The present review article will discuss current evidence regarding the prevalence of EPI, the available tests to diagnose it and its treatment.
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页码：129 / 139
页数：11
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