The role of hypoxia in pulmonary vascular diseases: a perspective

被引：43
作者：
Voelkel, Norbert F. [1 ]
Mizuno, Shiro [2 ]
Bogaard, Harm J. [3 ]
机构：
[1] Virginia Commonwealth Univ, Victoria Johnson Lab Lung Res, Pulm & Crit Care Med Div, Richmond, VA USA
[2] Kanazawa Med Univ, Div Resp Dis, Kanazawa, Ishikawa, Japan
[3] Vrije Univ Amsterdam, Med Ctr, Dept Pulm, NL-1007 MB Amsterdam, Netherlands
来源：
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY | 2013年 / 304卷 / 07期
关键词：
hypoxia; pulmonary hypertension; hypoxia-inducible factor; inflammation; epigenitics; TO-MESENCHYMAL TRANSITION; INDUCIBLE FACTOR-I; ENDOTHELIAL GROWTH-FACTOR; LUNG MAST-CELLS; NF-KAPPA-B; ARTERIAL-HYPERTENSION; TRANSCRIPTIONAL REGULATION; SMOOTH-MUSCLE; HIGH-ALTITUDE; SPHINGOSINE; 1-PHOSPHATE;
D O I：
10.1152/ajplung.00335.2012
中图分类号：
Q4 [生理学];
学科分类号：
071003 ;
摘要：
Voelkel NF, Mizuno S, Bogaard HJ. The role of hypoxia in pulmonary vascular diseases: a perspective. Am J Physiol Lung Cell Mol Physiol 304: L457-L465, 2013. First published February 1, 2013; doi:10.1152/ajplung.00335.2012.-From the discovery of hypoxic pulmonary vasoconstriction, responses to hypoxia have been considered as representative for the many alterations in lung vessels that occur in several chronic lung diseases, including pulmonary hypertension, interstitial pulmonary fibrosis, acute respiratory distress syndrome, and chronic obstructive pulmonary disease. An essential part of preclinical research to explain the pathobiology of these diseases has been centered on the exposure of small and large animals to hypoxia. This review aims to summarize pivotal results of clinical and preclinical research on hypoxia, which still have important implications for researchers today.
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收藏
页码：L457 / L465
页数：9
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