Phenolic profiling and evaluation of in vitro antioxidant, α-glucosidase and α-amylase inhibitory activities of Lepisanthes fruticosa (Roxb) Leenh fruit extracts

被引：48
作者：
Salahuddin, Mirfat Ahmad Hasan [1 ,2 ]
Ismail, Amin [1 ]
Kassim, Nur Kartinee [3 ]
Hamid, Muhajir [4 ]
Ali, Mohd Shukri Mat [2 ]
机构：
[1] Univ Putra Malaysia, Fac Med & Hlth Sci, Dept Nutr & Dietet, Res Ctr Excellence Nutr & Noncommunicable Dis, Serdang 43400, Selangor, Malaysia
[2] Persiaran MARDI UPM, Malaysian Agr Res & Dev Inst, Serdang 43400, Selangor, Malaysia
[3] Univ Putra Malaysia, Dept Chem, Fac Sci, Serdang 43400, Selangor, Malaysia
[4] Univ Putra Malaysia, Fac Biotechnol & Biomol Sci, Dept Microbiol, Serdang 43400, Selangor, Malaysia
来源：
FOOD CHEMISTRY | 2020年 / 331卷 / 331期
关键词：
Lepisanthes fruticosa; Antioxidant; alpha-Glucosidase; alpha-Amylase; LC-MS/MS; Phenolics; ANTIDIABETIC ACTIVITY; L; LEAVES; POLAR; PARTS; PEEL; VIVO;
D O I：
10.1016/j.foodchem.2020.127240
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
The present study focused on the phytochemical profiling along with evaluation of in vitro antioxidant, alpha-glucosidase and alpha-amylase inhibitory activities of various crudes and fractions obtained from Lepisanthes fruticosa (Roxb) Leenh fruit. Ethanolic seed crude extract exhibited the strongest radical scavenging, beta-carotene bleaching activity, alpha-glucosidase inhibition and the highest total phenolic content (TPC). Column chromatography afforded various fractions with fraction M4 being the most potent due to the strongest radical scavenging, beta carotene bleaching, alpha-glucosidase inhibition and greatest amount of TPC. Liquid chromatography-tandem mass spectrometry (LC-MS/MS) analysis of ethanolic seed crude extract and fraction M4 showed the presence of various phytochemicals with antioxidant and antidiabetic properties, which include mostly flavonoids and tannins. The results may suggest that the ethanolic crude seed extract and its fraction could be an excellent source of bioactive phytochemicals with antioxidant and antidiabetic potential.
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页数：10
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