Protective Effects of Zinc on Testes of Cadmium-Treated Rats

被引：32
作者：
Burukoglu, Dilek [3 ]
Baycu, Cengiz [1 ,2 ,3 ]
机构：
[1] Eskisehir Osmangazi Univ, Dept Histol, TR-26040 Eskisehir, Turkey
[2] Eskisehir Osmangazi Univ, Embryol Med Fac, TR-26040 Eskisehir, Turkey
[3] Eskisehir Osmangazi Univ, Fac Med, Dept Histol & Embryol, TR-26040 Eskisehir, Turkey
来源：
BULLETIN OF ENVIRONMENTAL CONTAMINATION AND TOXICOLOGY | 2008年 / 81卷 / 06期
关键词：
Cadmium; testicular damage; Zinc; Rat;
D O I：
10.1007/s00128-007-9211-x
中图分类号：
X [环境科学、安全科学];
学科分类号：
08 ; 0830 ;
摘要：
In this microscopic study, the toxic effects of cadmium (Cd) and the protective role of a zinc (Zn) co-treatment were investigated in the testes of the rats treated with Cd. At the dose and duration used, Cd severely damaged the seminiferous tubules and caused the degeneration and disintegration of spermatogenic cells. Leydig cells were also lost after Cd treatment. The present study showed that zinc co-treatment protected testes against toxic effects of cadmium.
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收藏
页码：521 / 524
页数：4
相关论文
共 12 条
  • [1] Afonne Onyenmechi J., 2002, Indian Journal of Pharmacology, V34, P26
  • [2] Immunohistochemical and ultrastructural changes in the renal cortex of cadmium-treated rats
    Asar, M
    Kayisli, ÜA
    Izgüt-Uysal, VN
    Akkoyunlu, G
    [J]. BIOLOGICAL TRACE ELEMENT RESEARCH, 2004, 97 (03) : 249 - 263
  • [3] The effect of zinc supplementation on the effects of lead on the rat testis
    Batra, N
    Nehru, B
    Bansal, MP
    [J]. REPRODUCTIVE TOXICOLOGY, 1998, 12 (05) : 535 - 540
  • [4] Protective effects of zinc on cadmium toxicity in rodents
    Claverie, C
    Corbella, R
    Martín, D
    Díaz, C
    [J]. BIOLOGICAL TRACE ELEMENT RESEARCH, 2000, 75 (1-3) : 1 - 9
  • [5] Metallothionein: An intracellular protein to protect against cadmium toxicity
    Klaassen, CD
    Liu, J
    Choudhuri, S
    [J]. ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY, 1999, 39 : 267 - 294
  • [6] Patrick Lyn, 2003, Altern Med Rev, V8, P106
  • [7] Evidence supporting zinc as an important antioxidant for skin
    Rostan, EF
    DeBuys, HV
    Madey, DL
    Pinnell, SR
    [J]. INTERNATIONAL JOURNAL OF DERMATOLOGY, 2002, 41 (09) : 606 - 611
  • [8] SAXENA DK, 1989, RES COMMUN CHEM PATH, V64, P317
  • [9] Cadmium carcinogenesis in review
    Waalkes, MP
    [J]. JOURNAL OF INORGANIC BIOCHEMISTRY, 2000, 79 (1-4) : 241 - 244
  • [10] WORLD HEALTH ORGANIZATION (WHO), 1992, CAD ENV HLTH CRIT
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