MiR-125 in normal and malignant hematopoiesis

被引：154
作者：
Shaham, L. [1 ,2 ]
Binder, V. [3 ,4 ,5 ]
Gefen, N. [1 ,6 ]
Borkhardt, A. [3 ]
Izraeli, S. [1 ,6 ]
机构：
[1] Chaim Sheba Med Ctr, Canc Res Ctr, Dept Pediat Hematooncol Funct Genom & Childhood L, IL-52621 Tel Hashomer, Ramat Gan, Israel
[2] Bar Ilan Univ, Mina & Everard Goodman Fac Life Sci, Ramat Gan, Israel
[3] Univ Dusseldorf, Fac Med, Dept Pediat Oncol Hematol & Clin Immunol, D-40225 Dusseldorf, Germany
[4] Harvard Univ, Sch Med, Harvard Stem Cell Inst, Div Hematol Oncol,Childrens Hosp, Boston, MA USA
[5] Harvard Univ, Sch Med, Harvard Stem Cell Inst, Childrens Hosp,Stem Cell Program, Boston, MA USA
[6] Tel Aviv Univ, Sackler Fac Med, IL-69978 Tel Aviv, Israel
来源：
LEUKEMIA | 2012年 / 26卷 / 09期
基金：
美国国家卫生研究院;
关键词：
microRNA; hematopoiesis; hematological malignancies; acute myeloid leukemia; acute lymphoblastic leukemia; ACUTE LYMPHOBLASTIC-LEUKEMIA; ACUTE MYELOID-LEUKEMIA; MICRORNA EXPRESSION PROFILES; CELL-DIFFERENTIATION; UROTHELIAL CARCINOMAS; MIRNA EXPRESSION; TUMOR-SUPPRESSOR; BAK1; EXPRESSION; PROSTATE-CANCER; BREAST-CANCER;
D O I：
10.1038/leu.2012.90
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
MiR-125 is a highly conserved microRNA throughout many different species from nematode to humans. In humans, there are three homologs (hsa-miR-125b-1, hsa-miR-125b-2 and hsa-miR-125a). Here we review a recent research on the role of miR-125 in normal and malignant hematopoietic cells. Its high expression in hematopoietic stem cells (HSCs) enhances self-renewal and survival. Its expression in specific subtypes of myeloid and lymphoid leukemias provides resistance to apoptosis and blocks further differentiation. A direct oncogenic role in the hematopoietic system has recently been demonstrated by several mouse models. Targets of miR-125b include key proteins regulating apoptosis, innate immunity, inflammation and hematopoietic differentiation.
引用
收藏
页码：2011 / 2018
页数：8
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