Early Insights into Immune Responses during COVID-19

被引：41

作者：

John, Ashley L. St. ^{[1
,2
,3
,4
]}

Rathore, Abhay P. S. ^{[4
]}

机构：

[1] Duke Natl Univ Singapore, Programme Emerging Infect Dis, Singapore 169857, Singapore

[2] Natl Univ Singapore, Yong Loo Lin Sch Med, Dept Microbiol & Immunol, Singapore 117545, Singapore

[3] Duke Natl Univ Singapore, Global Hlth Inst, SingHlth, Singapore 168753, Singapore

[4] Duke Univ, Med Ctr, Dept Pathol, Durham, NC 27705 USA

来源：

JOURNAL OF IMMUNOLOGY | 2020年 / 205卷 / 03期

基金：

英国医学研究理事会; 新加坡国家研究基金会;

关键词：

FELINE INFECTIOUS PERITONITIS; RESPIRATORY SYNDROME SARS; CORONAVIRUS; SARS-COV-2; RECEPTOR; ACE2; TMPRSS2;

D O I：

10.4049/jimmunol.2000526

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Coronavirus disease-2019 (COVID-19) is caused by the newly emerged virus severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and was recently declared as a pandemic by the World Health Organization. In its severe form, the disease is characterized by acute respiratory distress syndrome, and there are no targeted intervention strategies to treat or prevent it. The immune response is thought to both contribute to the pathogenesis of disease and provide protection during its resolution. Thus, understanding the immune response to SARS-CoV-2 is of the utmost importance for developing and testing vaccines and therapeutics. In this review, we discuss the earliest knowledge and hypotheses of the mechanisms of immune pathology in the lung during acute infection as well at the later stages of disease resolution, recovery, and immune memory formation.

引用

页码：555 / 564

页数：10

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