Inhibition of JAK2/STAT3 Pathway Leads to Apoptosis in Chronic Lymphocytic Leukemia Cells

被引:0
|
作者
Severin, Filippo [1 ,2 ]
Frezzato, Federica [1 ,2 ]
Martini, Veronica [1 ,2 ]
Raggi, Flavia [1 ,2 ]
Trimarco, Valentina [1 ,2 ]
Martinello, Leonardo [1 ,2 ]
Visentin, Andrea [1 ,2 ]
Facco, Monica [1 ,2 ]
Semenzato, Gianpietro [1 ,2 ]
Trentin, Livio [3 ,4 ]
机构
[1] Univ Padua, Dept Med, Hematol & Clin Immunol Unit, Padua, Italy
[2] Venetian Inst Mol Med VIMM, Padua, Italy
[3] Venetian Inst Mol Med VIMM, Pada, Italy
[4] Univ Padua, Dept Med Hematol, Padua, Italy
关键词
D O I
10.1182/blood.V128.22.2023.2023
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
2023
引用
收藏
页数:4
相关论文
共 50 条
  • [1] JAK2/STAT3 PATHWAY INHIBITION REDUCES CHRONIC LYMPHOCYTIC LEUKEMIA CELL VIABILITY
    Severin, F.
    Frezzato, F.
    Pizzo, S.
    Trimarco, V.
    Visentin, A.
    Imbergamo, S.
    Semenzato, G.
    Facco, M.
    Trentin, L.
    HAEMATOLOGICA, 2019, 104 : 37 - 37
  • [2] JAK2/STAT3 PATHWAY INVOLVEMENT IN CHRONIC LYMPHOCYTIC LEUKEMIA CELL VIABILITY
    Severin, F.
    Frezzato, F.
    Martini, V.
    Raggi, F.
    Trimarco, V.
    Visentin, A.
    Imbergamo, S.
    Semenzato, G.
    Facco, M.
    Trentin, L.
    HAEMATOLOGICA, 2018, 103 : S76 - S76
  • [3] Chronic Lymphocytic Leukemia: JAK2/STAT3 pathway dysregulation involvement in neoplastic clone survival
    Trentin, Livio
    Severin, Filippo
    Frezzato, Federica
    Martini, Veronica
    Raggi, Flavia
    Trimarco, Valentina
    Martinello, Leonardo
    Visentin, Andrea
    Scomazzon, Edoardo
    Facco, Monica
    LEUKEMIA & LYMPHOMA, 2017, 58 : 171 - 172
  • [4] Stimulation of the B-cell receptor activates the JAK2/STAT3 signaling pathway in chronic lymphocytic leukemia cells
    Rozovski, Uri
    Wu, Ji Yuan
    Harris, David M.
    Liu, Zhiming
    Li, Ping
    Hazan-Halevy, Inbal
    Ferrajoli, Alessandra
    Burger, Jan A.
    O'Brien, Susan
    Jain, Nitin
    Verstovsek, Srdan
    Wierda, William G.
    Keating, Michael J.
    Estrov, Zeev
    BLOOD, 2014, 123 (24) : 3797 - 3802
  • [5] In Chronic Lymphocytic Leukemia the JAK2/STAT3 Pathway Is Constitutively Activated and Its Inhibition Leads to CLL Cell Death Unaffected by the Protective Bone Marrow Microenvironment
    Severin, Filippo
    Frezzato, Federica
    Visentin, Andrea
    Martini, Veronica
    Trimarco, Valentina
    Carraro, Samuela
    Tibaldi, Elena
    Brunati, Anna Maria
    Piazza, Francesco
    Semenzato, Gianpietro
    Facco, Monica
    Trentin, Livio
    CANCERS, 2019, 11 (12)
  • [6] Inhibition of cerebral ischemia/reperfusion injuryinduced apoptosis: nicotiflorin and JAK2/STAT3 pathway
    Guang-qiang Hu
    Xi Du
    Yong-jie Li
    Xiao-qing Gao
    Bi-qiong Chen
    Lu Yu
    Neural Regeneration Research, 2017, 12 (01) : 96 - 102
  • [7] Targeting the JAK2/STAT3 signaling pathway for chronic pain
    Dai, Xin-Yi
    Liu, Lin
    Song, Fan-He
    Gao, Shao-Jie
    Wu, Jia-Yi
    Li, Dan-Yang
    Zhang, Long-Qing
    Liu, Dai-Qiang
    Zhou, Ya-Qun
    Mei, Wei
    AGING AND DISEASE, 2024, 15 (01): : 186 - 200
  • [8] Resveratrol Induces Cell Cycle Arrest and Apoptosis in Malignant NK Cells via JAK2/STAT3 Pathway Inhibition
    Trung, Ly Quoc
    Espinoza, J. Luis
    Takami, Akiyoshi
    Nakao, Shinji
    PLOS ONE, 2013, 8 (01):
  • [9] Resveratrol Induces Cell Cycle Arrest and Apoptosis in Malignant NK Cells Via JAK2/STAT3 Pathway Inhibition
    Ly Quoc Trung
    Espinoza, Luis Jorge
    Takami, Akiyoshi
    Yoshida, Akiyo
    Nakao, Shinji
    BLOOD, 2012, 120 (21)
  • [10] Cinnamaldehyde Regulates the Migration and Apoptosis of Gastric Cancer Cells by Inhibiting the Jak2/Stat3 Pathway
    Geng, Yuan-yuan
    Yang, Shuo
    Liu, Zhi-hao
    Wang, Si-yu
    Ge, Pan
    DIGESTIVE DISEASES AND SCIENCES, 2024, 69 (08) : 2875 - 2882