Penicillium spp.: prolific producer for harnessing cytotoxic secondary metabolites

被引：43

作者：

Koul, Mytre ^{[1
,2
]}

Singh, Shashank ^{[1
,2
]}

机构：

[1] CSIR Indian Inst Integrat Med, Canc Pharmacol Div, Canal Rd, Jammu 180001, Jammu & Kashmir, India

[2] CSIR, Acad Sci & Innovat Res AcSIR, New Delhi, India

来源：

ANTI-CANCER DRUGS | 2017年 / 28卷 / 01期

关键词：

anticancer agents; cancer; cytotoxic; dicatenarin; endophytes; endophytic fungi; fungi; Penicillium spp; secondary metabolites; EMODIN INDUCES APOPTOSIS; MARINE-DERIVED FUNGUS; PROTEIN FARNESYLTRANSFERASE INHIBITORS; BREAST-CANCER CELLS; SECALONIC ACID D; BREFELDIN-A; MYCOPHENOLATE-MOFETIL; ENDOPHYTIC FUNGUS; ANTITUMOR-ACTIVITY; IN-VITRO;

D O I：

10.1097/CAD.0000000000000423

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Secondary metabolites from fungal endophytes have become an interesting, attractive, and alternative source for novel pharmaceuticals. Several novel compounds with diversified chemical structures have been isolated from endophytic fungi. The genus Penicillium has been exploited worldwide for its biosynthetic potential for producing highly versatile cytotoxic secondary metabolites. Many of the compounds isolated from various species of the genus Penicillium have shown promising in-vitro as well as in-vivo growth-inhibitory properties against different human cancers. Thus, in relation to this genus, Penicillium represents the most dependable source of cytotoxic compounds with potential applications as leads for anticancer drugs. This review outlines endophytic secondary metabolites from the genus Penicillium with a relevant role as cytotoxic agents. Copyright (C) 2016 Wolters Kluwer Health, Inc. All rights reserved.

引用

页码：11 / 30

页数：20

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