Mast cell chymase regulates dermal mast cell number in mice

被引：25

作者：

Tomimori, Y ^{[1
]}

Muto, T ^{[1
]}

Fukami, H ^{[1
]}

Saito, K ^{[1
]}

Horikawa, C ^{[1
]}

Tsuruoka, N ^{[1
]}

Yamashiro, K ^{[1
]}

Saito, M ^{[1
]}

Sugiura, N ^{[1
]}

Sumida, M ^{[1
]}

Kakutani, S ^{[1
]}

Fukuda, Y ^{[1
]}

机构：

[1] Suntory Biomed Res Ltd, Osaka 6188503, Japan

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2002年 / 290卷 / 05期

关键词：

chymase; stem cell factor (SCF); mast cells; keratinocytes; dermatitis;

D O I：

10.1006/bbrc.2002.6365

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Chymase inhibitor reduced the increase in the number of dermal mast cells in 2,4-dinitrofluorobenzene-induced dermatitis in a dose-dependent manner. Intradermal injection of human chymase to mouse ear significantly increased histamine content, the marker for mast cell number in the skin. These results suggest that chymase released by mast cells may participate in local mast cell accumulation in a positive feedback fashion. Immunohistochemical analysis revealed that the intradermal injection of chymase reduces expression of stem cell factor (SCIP) on surface of the skin keratinocytes. In addition, incubation of human keratinocytes with chymase in vitro resulted in release of SCF into the culture medium. Since soluble SCF is thought to regulate mast cell number, the chymase-induced mast cell accumulation may occur via the ability of chymase to process membrane-bound SCIP on the epidermal keratinocytes. (C) 2002 Elsevier Science (USA).

引用

页码：1478 / 1482

页数：5

共 50 条

[11] Mast cell chymase in experimentally induced psoriasis
Suttle, Mireille-Maria
Harvima, Ilkka T.
JOURNAL OF DERMATOLOGY, 2016, 43 (06): : 693 - 696
[12] BIOLOGY OF MAST-CELL TRYPTASE AND CHYMASE
NADEL, JA
ANNALS OF THE NEW YORK ACADEMY OF SCIENCES, 1991, 629 : 319 - 331
[13] Mast cell chymase degrades fibrinogen and fibrin
Lipitsa, T.
Siiskonen, H.
Naukkarinen, A.
Harvima, I. T.
BRITISH JOURNAL OF DERMATOLOGY, 2019, 181 (02) : 296 - 303
[14] Inhibitors of chymase as mast cell-stabilizing agents:: Contribution of chymase in the activation of human mast cells
He, SH
Gaça, MDA
McEuen, AR
Walls, AF
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 1999, 291 (02): : 517 - 523
[15] Mast cell chymase induces programmed cell death.
Chan, IJ
Tharp, MD
JOURNAL OF INVESTIGATIVE DERMATOLOGY, 1997, 108 (04) : 195 - 195
[16] SHEEP MAST-CELL PROTEINASE (SMCP), A CHYMASE PRESENT IN OVINE DERMAL MAST-CELLS, EVOKES DERMAL NEUTROPHIL INFLUX IN THE HOMOLOGOUS HOST
STURE, G
HUNTLEY, J
PEMBERTON, A
MACKELLAR, A
MILLER, H
JOURNAL OF INVESTIGATIVE DERMATOLOGY, 1995, 105 (05) : 61 - 61
[17] Histochemical and ultrastructural modification of mucosal mast cell granules in parasitized mice lacking the β-chymase, mouse mast cell protease-1
Wastling, JM
Knight, P
Ure, J
Wright, S
Thornton, EM
Scudamore, CL
Mason, J
Smith, A
Miller, HRP
AMERICAN JOURNAL OF PATHOLOGY, 1998, 153 (02): : 491 - 504
[18] Association between the expression of mast cell chymase and intraperitoneal adhesion formation in mice
Yao, YL
Ishihara, T
Takai, S
Miyazaki, M
Mita, S
JOURNAL OF SURGICAL RESEARCH, 2000, 92 (01) : 40 - 44
[19] Involvement of mast cell chymase in bleomycin-induced pulmonary fibrosis in mice
Tomimori, Y
Muto, T
Saito, K
Tanaka, T
Maruoka, H
Sumida, M
Fukami, H
Fukuda, Y
EUROPEAN JOURNAL OF PHARMACOLOGY, 2003, 478 (2-3) : 179 - 185
[20] Role for mast cell chymase in intestinal epithelial permeability
Groschwitz, K. R.
Ahrens, R.
Finkehman, F. D.
Abonia, J. P.
Gurish, M. F.
Rothenberg, M. E.
Hogan, S. P.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2008, 121 (02) : S110 - S110

← 1 2 3 4 5 →