Experimental models and mechanisms underlying the protective effects of n-3 polyunsaturated fatty acids in Alzheimer's disease

被引：82

作者：

Boudrault, Cynthia ^{[2
]}

Bazinet, Richard P. ^{[2
]}

Ma, David W. L. ^{[1
,2
]}

机构：

[1] Univ Guelph, Dept Human Hlth & Nutr Sci, Coll Biol Sci, Guelph, ON N1G 2W1, Canada

[2] Univ Toronto, Fac Med, Dept Nutr Sci, Toronto, ON M5S 3E2, Canada

来源：

JOURNAL OF NUTRITIONAL BIOCHEMISTRY | 2009年 / 20卷 / 01期

基金：

加拿大自然科学与工程研究理事会;

关键词：

n-3; PUFA; Alzheimer's Disease; DHA; Fish oil; Mouse models; ALPHA-LINOLENIC ACID; BETA-INFUSED RATS; DOCOSAHEXAENOIC ACID; AMYLOID-BETA; LEARNING-ABILITY; LIPID RAFTS; COGNITIVE DECLINE; FRONTAL-CORTEX; BRAIN; RISK;

D O I：

10.1016/j.jnutbio.2008.05.016

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Dementia such as Alzheimer's disease (AD) is a growing health problem in aging populations in many countries around the world. Currently, there is no cure for AD; consequently, alternative therapies are urgently needed. Recent studies suggest that nutritional intervention may have therapeutic benefits for AD. Specifically, an increased intake of n-3 polyunsaturated fatty acids (PUFA) from fish and marine oils may lower AD risk. This review will summarize the current body of knowledge regarding the association between n-3 PUFA and AD, including human studies and experimental models, and potential mechanisms of action. (C) 2009 Elsevier Inc. All rights reserved.

引用

页码：1 / 10

页数：10

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