The discovery of natalizumab, a potent therapeutic for multiple sclerosis

被引：61

作者：

Steinman, Lawrence ^{[1
,2
]}

机构：

[1] Stanford Univ, Dept Pediat, Stanford, CA 94305 USA

[2] Stanford Univ, Dept Neurol & Neurol Sci, Interdept Program Immunol, Stanford, CA 94305 USA

来源：

JOURNAL OF CELL BIOLOGY | 2012年 / 199卷 / 03期

关键词：

EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS; CEREBROSPINAL-FLUID; OSTEOPONTIN LEVELS; PREVENTION; RISK; LYMPHOCYTES; ANTIBODIES; RECEPTOR; REVEALS; DISEASE;

D O I：

10.1083/jcb.201207175

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Multiple sclerosis (MS) is the major inflammatory demyelinating disease of the central nervous system. There is strong evidence that an immune response in the brain is a critical component of the disease. In 1992, in a collaboration between academia and biotechnology, my colleagues and I showed that. 4 integrin was the critical molecule involved in the homing of immune cells into the inflamed brain. Was it sheer luck that these results led to the development of a drug for MS?

引用

页码：413 / 416

页数：4

共 33 条

[1] Small integrin-binding ligand N-linked glycoproteins (SIBLINGs): multifunctional proteins in cancer [J].

Bellahcene, Akeila ;

Castronovo, Vincent ;

Ogbureke, Kalu U. E. ;

Fisher, Larry W. ;

Fedarko, Neal S. .

NATURE REVIEWS CANCER, 2008, 8 (03) :212-226

[2] Risk of Natalizumab-Associated Progressive Multifocal Leukoencephalopathy [J].

Bloomgren, Gary ;

Richman, Sandra ;

Hotermans, Christophe ;

Subramanyam, Meena ;

Goelz, Susan ;

Natarajan, Amy ;

Lee, Sophia ;

Plavina, Tatiana ;

Scanlon, James V. ;

Sandrock, Alfred ;

Bozic, Carmen .

NEW ENGLAND JOURNAL OF MEDICINE, 2012, 366 (20) :1870-1880

[3] Osteopontin concentrations are increased in cerebrospinal fluid during attacks of multiple sclerosis [J].

Bornsen, Lars ;

Khademi, Mohsen ;

Olsson, Tomas ;

Sorensen, Per Soelberg ;

Sellebjerg, Finn .

MULTIPLE SCLEROSIS JOURNAL, 2011, 17 (01) :32-42

[4] Plasma osteopontin levels in multiple sclerosis [J].

Comabella, M ;

Pericot, I ;

Goertsches, R ;

Nos, C ;

Castillo, M ;

Navarro, JB ;

Río, J ;

Montalban, X .

JOURNAL OF NEUROIMMUNOLOGY, 2005, 158 (1-2) :231-239

[5] Medical progress: Multiple sclerosis - The plaque and its pathogenesis [J].

Frohman, EM ;

Racke, MK ;

Raine, CS .

NEW ENGLAND JOURNAL OF MEDICINE, 2006, 354 (09) :942-955

[6] A CELL-SURFACE MOLECULE INVOLVED IN ORGAN-SPECIFIC HOMING OF LYMPHOCYTES [J].

GALLATIN, WM ;

WEISSMAN, IL ;

BUTCHER, EC .

NATURE, 1983, 304 (5921) :30-34

[7] Anti-JC Virus Antibodies: Implications for PML Risk Stratification [J].

Gorelik, Leonid ;

Lerner, Michaela ;

Bixler, Sarah ;

Crossman, Mary ;

Schlain, Brian ;

Simon, Kenneth ;

Pace, Amy ;

Cheung, Anne ;

Chen, Ling Ling ;

Berman, Melissa ;

Zein, Fairuz ;

Wilson, Ewa ;

Yednock, Ted ;

Sandrock, Alfred ;

Goelz, Susan E. ;

Subramanyam, Meena .

ANNALS OF NEUROLOGY, 2010, 68 (03) :295-303

[8] ROUTE OF RE-CIRCULATION OF LYMPHOCYTES IN RAT [J].

GOWANS, JL ;

KNIGHT, EJ .

PROCEEDINGS OF THE ROYAL SOCIETY SERIES B-BIOLOGICAL SCIENCES, 1964, 159 (975) :257-+

[9] Proteomic analysis of active multiple sclerosis lesions reveals therapeutic targets [J].

Han, May H. ;

Hwang, Sun-Il ;

Roy, Dolly B. ;

Lundgren, Deborah H. ;

Price, Jordan V. ;

Ousman, Shalina S. ;

Fernald, Guy Haskin ;

Gerlitz, Bruce ;

Robinson, William H. ;

Baranzini, Sergio E. ;

Grinnell, Brian W. ;

Raine, Cedric S. ;

Sobel, Raymond A. ;

Han, David K. ;

Steinman, Lawrence .

NATURE, 2008, 451 (7182) :1076-U2

[10] Identification of Naturally Occurring Fatty Acids of the Myelin Sheath That Resolve Neuroinflammation [J].

Ho, Peggy P. ;

Kanter, Jennifer L. ;

Johnson, Amanda M. ;

Srinagesh, Hrishikesh K. ;

Chang, Eun-Ju ;

Purdy, Timothy M. ;

van Haren, Keith ;

Wikoff, William R. ;

Kind, Tobias ;

Khademi, Mohsen ;

Matloff, Laura Y. ;

Narayana, Sirisha ;

Hur, Eun Mi ;

Lindstrom, Tamsin M. ;

He, Zhigang ;

Fiehn, Oliver ;

Olsson, Tomas ;

Han, Xianlin ;

Han, May H. ;

Steinman, Lawrence ;

Robinson, William H. .

SCIENCE TRANSLATIONAL MEDICINE, 2012, 4 (137)

← 1 2 3 4 →