Design, synthesis, biological evaluation of thiazolyl schiff base derivatives as novel anti-inflammatory agents

被引：0

作者：

Bhosale, P. P. ^{[1
]}

Chavan, R. S. ^{[1
]}

Bhosale, A. V. ^{[1
]}

机构：

[1] Seth Govind Raghunath Sable Coll Pharm, Poona Dist Educ Assoc, Dept Pharmaceut Chem, Pune 412301, Maharashtra, India

来源：

INDIAN JOURNAL OF CHEMISTRY SECTION B-ORGANIC CHEMISTRY INCLUDING MEDICINAL CHEMISTRY | 2012年 / 51卷 / 11期

关键词：

Thiazole; Schiff base; anti-inflammatory activity; analgesic activity; ulcerogenic activity; COMPLEXES;

D O I：

暂无

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A series of new 4-(4-substitutedphenyl)-N-(4-substitutedbenzylidene)-thiazol-2-amine derivatives 5a-I has been synthesized and evaluated for their anti-inflammatory and analgesic activities at a dose of 50 mg/kg p.o. The most active compounds 5a, 5j have been subjected to acute ulcerogenesis study at a dose of 150 mg/kg. The structure of all these compounds have been established on the basis of spectral (IR, H-1 NMR data) studies.

引用

页码：1649 / 1654

页数：6

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