Asymmetric alkylation of diarylmethane derivatives

被引：53
作者：
Wilkinson, JA
Rossington, SB
Ducki, S
Leonard, J
Hussain, N
机构：
[1] Univ Salford, Ctr Drug Design, Biosci Res Inst, Salford M5 4WT, Lancs, England
[2] AstraZeneca Proc R&D, Macclesfield SK10 2NG, Cheshire, England
[3] GlaxoSmithKline Chem Dev, Tonbridge TN11 9AN, Kent, England
来源：
TETRAHEDRON | 2006年 / 62卷 / 08期
关键词：
asymmetric; alkylation; diarylmethane; sparteine;
D O I：
10.1016/j.tet.2005.11.044
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Deprotonation-alkylation of prochiral diarylinethane substrates using sec-BuLi and (-)-sparteine has been carried Out in excellent yields and Lip to 94% ee. A variety of enantioselective alkylations, silylations and stannylations have been performed on four different diarylmethanes. Surrogates for (+)-sparteine have also been applied in this Study including a novel surrogate. (c) 2005 Elsevier Ltd. All rights reserved.
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收藏
页码：1833 / 1844
页数：12
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