Acaricides in modern management of plant-feeding mites

This review focuses on biological profiles of contemporary acaricides, acaricide resistance, and other up-to-date issues related to acaricide use in management of plant-feeding mites. Over the last two decades a considerable number of synthetic acaricides emerged on the global market, most of which exert their effects acting on respiration targets. Among them, the most important are inhibitors of mitochondrial electron transport at complex I (METI-acaricides). Discovery of tetronic acid derivatives (spirodiclofen and spiromesifen) introduced a completely new mode of action: lipid synthesis inhibition. Acaricide resistance in spider mites has become a global phenomenon. The resistance is predominantly caused by a less sensitive target site (target site resistance) and enhanced detoxification (metabolic resistance). The major emphasis in current research on acaricide resistance mechanisms deals with elucidation of their molecular basis. Point mutations resulting in structural changes of target site and leading to its reduced sensitivity, have recently been associated with resistance in Tetranychus urticae Koch and other spider mites. The only sustainable, long-term perspective for acaricide use is their implementation in multitactic integrated pest management programs, in which acaricides are applied highly rationally and in interaction with other control tactics. Considering that the key recommendation for effective acaricide resistance management is reduction of the selection for resistance by alternations, sequences, rotations, and mixtures of compounds with different modes of action, the main challenge that acaricide use is facing is the need for new active substances with novel target sites. Besides implementation of advanced technologies for screening and design of new synthetic compounds, wider use of microbial and plant products with acaricidal activity could also contribute increased biochemical diversity of acaricides.