Synthesis, structures and biological activity of some 4-amino-3-cinnoline-carboxylic acid derivatives .2.

被引：0

作者：

Stanczak, A ^{[1
]}

Lewgowd, W ^{[1
]}

Ochocki, Z ^{[1
]}

Pakulska, W ^{[1
]}

Szadowska, A ^{[1
]}

机构：

[1] MED UNIV LODZ, DEPT PHARMACODYNAM, PL-90151 LODZ, POLAND

来源：

PHARMAZIE | 1997年 / 52卷 / 02期

关键词：

D O I：

暂无

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

6,7,8-Substituted 4-amino-3-cinnolinecarboxylic acids 1 were condensed with amines to the corresponding 4-amino-3-cinnolinecarboxamides 7,8. A variety of pharmacological tests showed a significant CNS activity of some new amides. Decarboxylation of 4-amino-3-cinnolinecarboxylic acids 1 yielded the corresponding 4-aminocinnolines 4 and alkaline hydrolysis of 1 gave 4-oxo-3-cinnolinecarboxylic acids 2. The acids 1 were converted into pyrimido[5,4-c]cinnolines 6 on two ways of synthesis.

引用

页码：91 / 97

页数：7

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