Oligodendrogliogenesis and Axon Remyelination after Traumatic Spinal Cord Injuries in Animal Studies: A Systematic Review

被引：15

作者：

Hassannejad, Zahra ^{[1
,2
]}

Shakouri-Motlagh, Aida ^{[3
]}

Mokhatab, Mona ^{[4
]}

Zadegan, Shayan A. ^{[2
]}

Sharif-Alhoseini, Mahdi ^{[2
]}

Shokraneh, Farhad ^{[5
]}

Rahimi-Movaghar, Vafa ^{[2
]}

机构：

[1] Univ Tehran Med Sci, Pediat Urol & Regenerat Med Res Ctr, Childrens Hosp Med Ctr, Tehran, Iran

[2] Univ Tehran Med Sci, Sina Trauma & Surg Res Ctr, Tehran, Iran

[3] Univ Melbourne, Dept Chem & Biomol Engn, Melbourne, Vic, Australia

[4] Univ Sydney, Brain & Mind Ctr, Sydney, NSW, Australia

[5] Univ Nottingham, Inst Mental Hlth, Cochrane Schizophrenia Grp, Nottingham, England

来源：

NEUROSCIENCE | 2019年 / 402卷

关键词：

spinal cord injury; myelin; oligodendrocytes; Schwann cells; progenitors; oligodendrogliogenesis; SCHWANN-CELL TRANSPLANTATION; WALLERIAN DEGENERATION; COMPRESSION INJURY; NG2-POSITIVE CELLS; OLIGODENDROCYTE; CONTUSION; APOPTOSIS; RAT; PROLIFERATION; SURVIVAL;

D O I：

10.1016/j.neuroscience.2019.01.019

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Extensive oligodendrocyte death after acute traumatic spinal cord injuries (TSCI) leads to axon demyelination and subsequently may leave axons vulnerable to degeneration. Despite the present evidence showing spontaneous remyelination after TSCI the cellular origin of new myelin and the time course of the axon ensheathment/remyelination remained controversial issue. In this systematic review the trend of oligodendrocyte death after injury as well as the extent and the cellular origin of oligodendrogliogenesis were comprehensively evaluated. The study design was based on Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA)-guided systematic review. PubMed and EMBASE were searched with no temporal or linguistic restrictions. Also, hand-search was performed in the bibliographies of relevant articles. Non-interventional animal studies discussing different types of myelinating cells including oligodendrocytes, Schwann cells and oligodendrocyte progenitor cells (OPCs) were evaluated. The extent of oligodendrocyte death, oligodendrocyte differentiation and remyelination were the pathophysiological outcome measures. We found 12,359 studies, 34 of which met the inclusion criteria. The cumulative evidence shows extensive oligodendrocytes cell death during the first week post-injury (pi). OPCs and peripheral invading Schwann cells are the dominant cells contributing in myelin formation. The maximum OPC proliferation was observed at around 2 weeks pi and oligodendrogliogenesis continues at later stages until the number of oligodendrocytes return to normal tissue by one month pi. Taken together, the evidence in animals reveals the potential role for endogenous myelinating cells in the axon ensheathment/remyelination after TSCI and this can be the target of pharmacotherapy to induce oligodendrocyte differentiation and myelin formation post-injury. (C) 2019 IBRO. Published by Elsevier Ltd. All rights reserved.

引用

页码：37 / 50

页数：14

共 66 条

[1] Apoptotic cells associated with wallerian degeneration after experimental spinal cord injury: A possible mechanism of oligodendroglial death [J].