Applications of the CRISPR-Cas9 system in cancer biology

被引：310

作者：

Sanchez-Rivera, Francisco J. ^{[1
,2
]}

Jacks, Tyler ^{[1
,2
,3
]}

机构：

[1] MIT, David H Koch Inst Integrat Canc Res, Cambridge, MA 02142 USA

[2] MIT, Dept Biol, Cambridge, MA 02142 USA

[3] MIT, Howard Hughes Med Inst, Cambridge, MA 02139 USA

来源：

NATURE REVIEWS CANCER | 2015年 / 15卷 / 07期

基金：

美国国家卫生研究院;

关键词：

ONE-STEP GENERATION; HUMAN-CELLS; CHROMOSOMAL TRANSLOCATIONS; HOMOLOGOUS RECOMBINATION; GENE-EXPRESSION; MOUSE MODELS; I-SCEI; CRISPR/CAS9; CAS9; ACTIVATION;

D O I：

10.1038/nrc3950

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The prokaryotic type II CRISPR-Cas9 (clustered regularly interspaced short palindromic repeats-CRISPR-associated 9) system is rapidly revolutionizing the field of genetic engineering, allowing researchers to alter the genomes of a large range of organisms with relative ease. Experimental approaches based on this versatile technology have the potential to transform the field of cancer genetics. Here, we review current approaches for functional studies of cancer genes that are based on CRISPR-Cas, with emphasis on their applicability for the development of next-generation models of human cancer.

引用

页码：387 / 395

页数：9

共 86 条

[1] Enhancing gene targeting with designed zinc finger nucleases [J].

Bibikova, M ;

Beumer, K ;

Trautman, JK ;

Carroll, D .

SCIENCE, 2003, 300 (5620) :764-764

[2]

Bibikova M, 2002, GENETICS, V161, P1169

[3] Programmable repression and activation of bacterial gene expression using an engineered CRISPR-Cas system [J].

Bikard, David ;

Jiang, Wenyan ;

Samai, Poulami ;

Hochschild, Ann ;

Zhang, Feng ;

Marraffini, Luciano A. .

NUCLEIC ACIDS RESEARCH, 2013, 41 (15) :7429-7437

[4] Simple and Rapid In Vivo Generation of Chromosomal Rearrangements using CRISPR/Cas9 Technology [J].

Blasco, Rafael B. ;

Karaca, Elif ;

Ambrogio, Chiara ;

Cheong, Taek-Chin ;

Karayol, Emre ;

Minero, Valerio G. ;

Voena, Claudia ;

Chiarle, Roberto .

CELL REPORTS, 2014, 9 (04) :1219-1227

[5] Characterization of Genomic Deletion Efficiency Mediated by Clustered Regularly Interspaced Palindromic Repeats (CRISPR)/Cas9 Nuclease System in Mammalian Cells [J].

Canver, Matthew C. ;

Bauer, Daniel E. ;

Dass, Abhishek ;

Yien, Yvette Y. ;

Chung, Jacky ;

Masuda, Takeshi ;

Maeda, Takahiro ;

Paw, Barry H. ;

Orkin, Stuart H. .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2014, 289 (31) :21312-21324

[6] MLL3 Is a Haploinsufficient 7q Tumor Suppressor in Acute Myeloid Leukemia [J].

Chen, Chong ;

Liu, Yu ;

Rappaport, Amy R. ;

Kitzing, Thomas ;

Schultz, Nikolaus ;

Zhao, Zhen ;

Shroff, Aditya S. ;

Dickins, Ross A. ;

Vakoc, Christopher R. ;

Bradner, James E. ;

Stock, Wendy ;

LeBeau, Michelle M. ;

Shannon, Kevin M. ;

Kogan, Scott ;

Zuber, Johannes ;

Lowe, Scott W. .

CANCER CELL, 2014, 25 (05) :652-665

[7] Genome-wide CRISPR Screen in a Mouse Model of Tumor Growth and Metastasis [J].

Chen, Sidi ;

Sanjana, Neville E. ;

Zheng, Kaijie ;

Shalem, Ophir ;

Lee, Kyungheon ;

Shi, Xi ;

Scott, David A. ;

Song, Jun ;

Pan, Jen Q. ;

Weissleder, Ralph ;

Lee, Hakho ;

Zhang, Feng ;

Sharp, Phillip A. .

CELL, 2015, 160 (06) :1246-1260

[8] A murine lung cancer co-clinical trial identifies genetic modifiers of therapeutic response [J].

Chen, Zhao ;

Cheng, Katherine ;

Walton, Zandra ;

Wang, Yuchuan ;

Ebi, Hiromichi ;

Shimamura, Takeshi ;

Liu, Yan ;

Tupper, Tanya ;

Ouyang, Jing ;

Li, Jie ;

Gao, Peng ;

Woo, Michele S. ;

Xu, Chunxiao ;

Yanagita, Masahiko ;

Altabef, Abigail ;

Wang, Shumei ;

Lee, Charles ;

Nakada, Yuji ;

Pena, Christopher G. ;

Sun, Yanping ;

Franchetti, Yoko ;

Yao, Catherine ;

Saur, Amy ;

Cameron, Michael D. ;

Nishino, Mizuki ;

Hayes, D. Neil ;

Wilkerson, Matthew D. ;

Roberts, Patrick J. ;

Lee, Carrie B. ;

Bardeesy, Nabeel ;

Butaney, Mohit ;

Chirieac, Lucian R. ;

Costa, Daniel B. ;

Jackman, David ;

Sharpless, Norman E. ;

Castrillon, Diego H. ;

Demetri, George D. ;

Jaenne, Pasi A. ;

Pandolfi, Pier Paolo ;

Cantley, Lewis C. ;

Kung, Andrew L. ;

Engelman, Jeffrey A. ;

Wong, Kwok-Kin .

NATURE, 2012, 483 (7391) :613-617

[9] Multiplexed activation of endogenous genes by CRISPR-on, an RNA-guided transcriptional activator system [J].

Cheng, Albert W. ;

Wang, Haoyi ;

Yang, Hui ;

Shi, Linyu ;

Katz, Yarden ;

Theunissen, Thorold W. ;

Rangarajan, Sudharshan ;

Shivalila, Chikdu S. ;

Dadon, Daniel B. ;

Jaenisch, Rudolf .

CELL RESEARCH, 2013, 23 (10) :1163-1171

[10] Targeted genome engineering in human cells with the Cas9 RNA-guided endonuclease [J].

Cho, Seung Woo ;

Kim, Sojung ;

Kim, Jong Min ;

Kim, Jin-Soo .

NATURE BIOTECHNOLOGY, 2013, 31 (03) :230-232

← 1 2 3 4 5 6 7 8 9 →