Circulating Cytokine Levels in Acute Pancreatitis-Model of SIRS/CARS Can Help in the Clinical Assessment of Disease Severity

被引：99
作者：
Gunjaca, Ivan [1 ]
Zunic, Josip [2 ]
Gunjaca, Mihaela [3 ]
Kovac, Zdenko [4 ]
机构：
[1] Univ Hosp Dubrava, Dept Med, Div Gastroenterol, Zagreb 10000, Croatia
[2] Gen Hosp Karlovac, Dept Intens Care Med, Karlovac, Croatia
[3] Gen Hosp Karlovac, Dept Med, Div Hematol, Karlovac, Croatia
[4] Univ Hosp Ctr Rebro, Dept Pathophysiol, Zagreb, Croatia
来源：
INFLAMMATION | 2012年 / 35卷 / 02期
关键词：
acute pancreatitis; cytokine level; SIRS; CARS; severity of disease; INTERLEUKIN-10 PROTECTS MICE; SEPSIS; NECROSIS; SIRS;
D O I：
10.1007/s10753-011-9371-z
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
The aim of our study was to evaluate the pro-and anti-inflammatory cytokine response during acute pancreatitis and its predictive value on severity of disease. A hospital-based prospective clinical study was conducted. Twenty patients with acute pancreatitis were enrolled during a 12-month period. Plasma concentrations of TNF-alpha, IL-1 beta, IL-6, and IL-10 were determined at days 1, 2, 3, 6, and 9. The patient population was analyzed by type of acute pancreatitis. Severity was defined according to the Atlanta criteria for assessing severity of acute pancreatitis. Clinical variables were recorded to patients classified in one of two groups: severe acute pancreatitis (SAP group) and mild acute pancreatitis (MILD group). Patients with SAP had significantly higher average levels of IL-6 compared to the MILD group patients (539.2 pg/L vs. 23.4 pg/L, p<0.0001). Also, the values of IL-10 were significantly higher in patients with SAP (242.4 pg/L vs. 8.1 pg/L, p=0.003). The values of TNF-alpha were not significantly different in both groups. The value of IL-6 and IL-10 showed a positive correlation (r=0.7964, p<0.0001). Although a relatively small sample of patients was used, we can conclude that the determination of the value of IL-6 and IL-10 can help in the clinical assessment of disease severity.
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收藏
页码：758 / 763
页数：6
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