Determination of free thyroid hormones

被引：77

作者：

Thienpont, Linda M. ^{[1
,2
]}

Van Uytfanghe, Katleen

Poppe, Kris ^{[3
,4
]}

Velkeniers, Brigitte ^{[3
,4
]}

机构：

[1] Univ Ghent, Fac Pharmaceut Sci, Mass Spectrometr Reference Lab, IFCC Comm Standardizat Thyroid Funct Test C STFT, B-9000 Ghent, Belgium

[2] Univ Ghent, Fac Pharmaceut Sci, Reference Lab, C STFT, B-9000 Ghent, Belgium

[3] Free Univ Brussels VUB, Univ Hosp Brussels, Dept Endocrinol, B-1090 Brussels, Belgium

[4] Free Univ Brussels VUB, Univ Hosp Brussels, Dept Gen Internal Med, B-1090 Brussels, Belgium

来源：

BEST PRACTICE & RESEARCH CLINICAL ENDOCRINOLOGY & METABOLISM | 2013年 / 27卷 / 05期

关键词：

thyrotropin; TSH; thyroxine; T4; tri-iodothyronine; T3; one-step labeled analog assay; one-step labeled antibody assay; two-step labeled analog assay; free T4 index; equilibrium dialysis; ultrafiltration; isotope dilution-liquid chromatographytandem mass spectrometry; international conventional reference measurement procedure; THYROTROPIN REFERENCE RANGE; TANDEM MASS-SPECTROMETRY; FREE-THYROXINE; FUNCTION TESTS; STIMULATING HORMONE; SERUM TSH; MATERNAL HYPOTHYROXINEMIA; EQUILIBRIUM DIALYSIS; EARLY-PREGNANCY; FREE T-4;

D O I：

10.1016/j.beem.2013.05.012

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Timely diagnosis and treatment of thyroid dysfunction is compelling given the prevalence and severity of the disease. It requires reliance on adequate laboratory testing of serum TSH as a hallmark in combination with free thyroxine/triiodothyronine. Free hormone methods have to accommodate variations in the concentration and binding capacity of binding proteins. This is a challenge because none of the methodologies developed so far measures the actual unbound hormone in serum. The indirect methods provide an approximation while the direct ones estimate the free hormone concentration either in the presence of the protein-bound counterpart, or after physical separation of the free from bound fraction. The ongoing controversy on the validity and lack of comparability of methodologies points to their imperfectness to reflect real in-vivo free hormone concentrations. Therefore, laboratories and clinicians should know the window of validity and limitations of their methods. The recently developed reference measurement system is a key advance towards improved standardization and clinical validity of free thyroid hormone measurements. (C) 2013 Elsevier Ltd. All rights reserved.

引用

页码：689 / 700

页数：12

共 72 条

[1] FT4 immunoassays may display a pattern during pregnancy similar to the equilibrium dialysis ID-LC/tandem MS candidate reference measurement procedure in spite of susceptibility towards binding protein alterations [J].

Anckaert, Ellen ;

Poppe, Kris ;

Van Uytfanghe, Katleen ;

Schiettecatte, Johan ;

Foulon, Walter ;

Thienpont, Linda M. .

CLINICA CHIMICA ACTA, 2010, 411 (17-18) :1348-1353

[2]

[Anonymous], 2006, UK GUID US THYR FUNC

[3] HYPERTHYROIDISM AND OTHER CAUSES OF THYROTOXICOSIS: MANAGEMENT GUIDELINES OF THE AMERICAN THYROID ASSOCIATION AND AMERICAN ASSOCIATION OF CLINICAL ENDOCRINOLOGISTS [J].

Bahn, Rebecca S. ;

Burch, Henry B. ;

Cooper, David S. ;

Garber, Jeffrey R. ;

Greenlee, Carol ;

Klein, Irwin ;

Laurberg, Peter ;

McDougall, I. Ross ;

Montori, Victor M. ;

Rivkees, Scott A. ;

Ross, Douglas S. ;

Sosa, Julie Ann ;

Stan, Marius N. .

ENDOCRINE PRACTICE, 2011, 17 (03) :456-520

[4] CURRENT ISSUES IN GLP-1 RECEPTOR AGONIST THERAPY FOR TYPE 2 DIABETES [J].

Bloomgarden, Zachary T. ;

Blonde, Lawrence ;

Garber, Alan J. ;

Wysham, Carol H. .

ENDOCRINE PRACTICE, 2012, 18 :6-26

[5] Is there a need to redefine the upper normal limit of TSH? [J].

Brabant, G. ;

Beck-Peccoz, P. ;

Jarzab, B. ;

Laurberg, P. ;

Orgiazzi, J. ;

Szaboics, I. ;

Weetman, A. P. ;

Wiersinga, W. M. .

EUROPEAN JOURNAL OF ENDOCRINOLOGY, 2006, 154 (05) :633-637

[6] Inaccuracies in Free Thyroid Hormone Measurement by Ultrafiltration and Tandem Mass Spectrometry [J].

Christofides, Nic D. ;

Midgley, John E. M. .

CLINICAL CHEMISTRY, 2009, 55 (12) :2228-2229

[7] The relationship between serum TSH and free T4 in older people [J].

Clark, Penny M. ;

Holder, Roger L. ;

Haque, Sayeed M. ;

Hobbs, F. D. Richard ;

Roberts, Lesley M. ;

Franklyn, Jayne A. .

JOURNAL OF CLINICAL PATHOLOGY, 2012, 65 (05) :463-465

[8]

CLSI, 2004, C45A CLSI

[9] Management of Thyroid Dysfunction during Pregnancy and Postpartum: An Endocrine Society Clinical Practice Guideline [J].

De Groot, Leslie ;

Abalovich, Marcos ;

Alexander, Erik K. ;

Amino, Nobuyuki ;

Barbour, Linda ;

Cobin, Rhoda H. ;

Eastman, Creswell J. ;

Lazarus, John H. ;

Luton, Dominique ;

Mandel, Susan J. ;

Mestman, Jorge ;

Rovet, Joanne ;

Sullivan, Scott .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2012, 97 (08) :2543-2565

[10]

Demers L.M., 2002, LAB MED PRACTICE GUI

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