Sonodynamic therapy inhibits angiogenesis and tumor growth in a xenograft mouse model

被引：94
作者：
Gao, Zhongxiuzi [1 ,2 ]
Zheng, Jinhua [1 ,2 ]
Yang, Bin [1 ]
Wang, Zhu [1 ]
Fan, Haixia [2 ]
Lv, Yanhong [2 ]
Li, Haixia [2 ]
Jia, Limin [2 ]
Cao, Wenwu [1 ,3 ]
机构：
[1] Harbin Inst Technol, Lab Sono & Phototheranost Technol, Harbin 150080, Peoples R China
[2] Harbin Med Univ, Basic Med Sci Coll, Dept Anat, Harbin 150081, Peoples R China
[3] Penn State Univ, Mat Res Inst, University Pk, PA 16802 USA
来源：
CANCER LETTERS | 2013年 / 335卷 / 01期
基金：
中国国家自然科学基金;
关键词：
Sonodynamic therapy; 5-Aminolevulinic acid; Anti-angiogenesis; Anti-tumor; LOW-INTENSITY ULTRASOUND; INDUCED PROTOPORPHYRIN IX; 5-AMINOLEVULINIC ACID; PHOTODYNAMIC THERAPY; ENDOTHELIAL-CELLS; APOPTOSIS; CANCER; DAMAGE; VEGF;
D O I：
10.1016/j.canlet.2013.02.006
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Studies of sonodynamic therapy (SDT) have mainly focused on its direct cytotoxic effect on tumor cells. Its effects on the tumor microenvironment, especially angiogenesis, remain unknown. In this study, we found that SDT significantly inhibited endothelial cell proliferation, migration, invasion, and tube formation. Furthermore, in a tumor xenograft mouse model, SDT was found to remarkably suppress tumor growth, intratumoral vascularity, and expression of vascular endothelial growth factor in tumor cells. An ultrastructural study showed damage and disruption of tumor microvasculature after STD. Our results indicate that SDT inhibits neovascularization in tumor, which is partially responsible for the anti-tumor effect of SDT. (c) 2013 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码：93 / 99
页数：7
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