The immune-sleep crosstalk in inflammatory bowel disease

被引：11

作者：

Eissa, Nour ^{[1
,2
,3
,4
]}

Mujawar, Quais ^{[5
]}

Alabdoulsalam, Tareq ^{[5
]}

Zohni, Sahar ^{[6
,7
]}

El-Matary, Wael ^{[2
,4
,5
]}

机构：

[1] Univ Manitoba, Dept Immunol, Winnipeg, MB, Canada

[2] Univ Manitoba, Childrens Hosp Res Inst Manitoba, Winnipeg, MB, Canada

[3] Univ Manitoba, Rady Fac Hlth Sci, Dept Internal Med, Sect Gastroenterol, Winnipeg, MB, Canada

[4] Univ Manitoba, IBD Clin & Res Ctr, Winnipeg, MB, Canada

[5] Univ Manitoba, Dept Pediat & Child Hlth, Winnipeg, MB, Canada

[6] Univ Alexandria, Fac Med, Dept Pediat, Alexandria, Egypt

[7] Childrens Hosp Eastern Ontario, Ottawa, ON, Canada

来源：

SLEEP MEDICINE | 2020年 / 73卷

基金：

加拿大健康研究院;

关键词：

Intestinal inflammation; Cytokines; Sleep disorders; INTESTINAL EPITHELIAL-CELLS; SLOW-WAVE SLEEP; ULCERATIVE-COLITIS; METABOLIC SYNDROME; APNEA SYNDROME; CARDIOVASCULAR-DISEASE; INTERMITTENT HYPOXIA; DEPRESSIVE SYMPTOMS; MACROPHAGE FUNCTION; INSUFFICIENT SLEEP;

D O I：

10.1016/j.sleep.2020.04.020

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Sleep disorders are progressively common and sometimes are associated with aberrant regulation of the adaptive and innate immune responses. Sleep interruption can increase the inflammatory burden by enhancing the pro-inflammatory cytokines particularly in patients with chronic diseases such as inflammatory bowel disease (IBD). IBD is a chronic inflammatory disease characterized by immune dysregulation, dysbiosis of gut microbiome, and poor-quality life. Therefore, this review highlights the crosstalk between sleep and immune responses during the progression of IBD. (C) 2020 Elsevier B.V. All rights reserved.

引用

页码：38 / 46

页数：9

共 174 条

[1] Diet, Gut Microbiome and Epigenetics: Emerging Links with Inflammatory Bowel Diseases and Prospects for Management and Prevention [J].