Disrupted anatomic networks in the 22q11.2 deletion syndrome

被引：4

作者：

Schmitt, J. Eric ^{[1
,2
]}

Yi, James ^{[1
,3
]}

Calkins, Monica E. ^{[1
]}

Ruparel, Kosha ^{[1
]}

Roalf, David R. ^{[1
]}

Cassidy, Amy ^{[1
]}

Souders, Margaret C. ^{[4
]}

Satterthwaite, Theodore D. ^{[1
]}

McDonald-McGinn, Donna M. ^{[4
,5
]}

Zackai, Elaine H. ^{[4
,5
]}

Gur, Ruben C. ^{[1
,2
]}

Emanuel, Beverly S. ^{[4
,5
]}

Gur, Raquel E. ^{[1
,2
]}

机构：

[1] Univ Penn, Dept Psychiat, Brain Behav Lab, Neuropsychiat Sect, Philadelphia, PA 19104 USA

[2] Hosp Univ Penn, Dept Radiol, Div Neuroradiol, 3400 Spruce St, Philadelphia, PA 19104 USA

[3] Childrens Hosp Philadelphia, Dept Child & Adolescent Psychiat, Philadelphia, PA 19104 USA

[4] Childrens Hosp Philadelphia, Div Human Genet, Philadelphia, PA 19104 USA

[5] Univ Penn, Dept Pediat, Perelman Sch Med, Philadelphia, PA 19104 USA

来源：

NEUROIMAGE-CLINICAL | 2016年 / 12卷

关键词：

22q11DS; cortical thickness; morphometry; network; MRI; schizophrenia; HUMAN CEREBRAL-CORTEX; BRAIN NETWORKS; CORTICAL THICKNESS; VELOCARDIOFACIAL SYNDROME; FUNCTIONAL CONNECTIVITY; ORGANIZATION; CHILDREN; SCHIZOPHRENIA; ABNORMALITIES; ADOLESCENTS;

D O I：

10.1016/j.nicl.2016.08.020

中图分类号：

R445 [影像诊断学];

学科分类号：

100207 ;

摘要：

The 22q11.2 deletion syndrome (22q11DS) is an uncommon genetic disorder with an increased risk of psychosis. Although the neural substrates of psychosis and schizophrenia are not well understood, aberrations in cortical networks represent intriguing potential mechanisms. Investigations of anatomic networks within 22q11DS are sparse. We investigated group differences in anatomic network structure in 48 individuals with 22q11DS and 370 typically developing controls by analyzing covariance patterns in cortical thickness among 68 regions of interest using graph theoretical models. Subjects with 22q11DS had less robust geographic organization relative to the control group, particularly in the occipital and parietal lobes. Multiple global graph theoretical statistics were decreased in 22q11DS. These results are consistent with prior studies demonstrating decreased connectivity in 22q11DS using other neuroimaging methodologies. (C) 2016 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY-NC-ND license.

引用

页码：420 / 428

页数：9