机构:
CNR, Ist Applicaz Calcolo M Picone IAC, I-00161 Rome, ItalyCNR, Ist Applicaz Calcolo M Picone IAC, I-00161 Rome, Italy
Castiglione, F
[1
]
Bernaschi, M
论文数: 0引用数: 0
h-index: 0
机构:
CNR, Ist Applicaz Calcolo M Picone IAC, I-00161 Rome, ItalyCNR, Ist Applicaz Calcolo M Picone IAC, I-00161 Rome, Italy
Bernaschi, M
[1
]
机构:
[1] CNR, Ist Applicaz Calcolo M Picone IAC, I-00161 Rome, Italy
来源:
INTERNATIONAL JOURNAL OF MODERN PHYSICS C
|
2005年
/
16卷
/
12期
关键词:
HIV-1;
computer simulations;
immunogenicity;
D O I:
10.1142/S0129183105008394
中图分类号:
TP39 [计算机的应用];
学科分类号:
081203 ;
0835 ;
摘要:
We simulate the progression of the HFV-1 infection in untreated host organisms. The phenotype features of the virus are represented by the replication rate, the probability of activating the transcription, the mutation rate and the capacity to stimulate an immune response (the so-called immunogenicity). It is very difficult to study in-vivo or in-vitro how these characteristics of the virus influence the evolution of the disease. Therefore we resorted to simulations based on a computer model validated in previous studies. We observe, by means of computer experiments, that the virus continuously evolves under the selective pressure of an immune response whose effectiveness downgrades along with the disease progression. The results of the simulations show that immunogenicity is the most important factor in determining the rate of disease progression but, by itself, it is not sufficient to drive the disease to a conclusion in all cases.
机构:
WRAIR, US Mil HIV Res Program, Silver Spring, MD USA
Henry M Jackson Fdn Adv Mil Med Inc, Bethesda, MD USAWRAIR, US Mil HIV Res Program, Silver Spring, MD USA
机构:
Icahn Sch Med Mt Sinai, Dept Med, Div Infect Dis, 1 Gustave L Levy Pl, New York, NY 10029 USAIcahn Sch Med Mt Sinai, Dept Med, Div Infect Dis, 1 Gustave L Levy Pl, New York, NY 10029 USA
Upadhyay, Chitra
Rao, Priyanka Gadam
论文数: 0引用数: 0
h-index: 0
机构:
Icahn Sch Med Mt Sinai, Dept Med, Div Infect Dis, 1 Gustave L Levy Pl, New York, NY 10029 USAIcahn Sch Med Mt Sinai, Dept Med, Div Infect Dis, 1 Gustave L Levy Pl, New York, NY 10029 USA
Rao, Priyanka Gadam
Feyznezhad, Roya
论文数: 0引用数: 0
h-index: 0
机构:
Icahn Sch Med Mt Sinai, Dept Med, Div Infect Dis, 1 Gustave L Levy Pl, New York, NY 10029 USAIcahn Sch Med Mt Sinai, Dept Med, Div Infect Dis, 1 Gustave L Levy Pl, New York, NY 10029 USA