The Importance of Additive and Non-Additive Mutational Effects in Protein Engineering

被引：138
|
作者：
Reetz, Manfred T. [1 ,2 ]
机构：
[1] Max Planck Inst Kohlenforsch, D-45470 Mulheim, Germany
[2] Univ Marburg, D-35032 Marburg, Germany
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2013年 / 52卷 / 10期
关键词：
directed evolution; enzymes; mutational additivity; mutational non-additivity; saturation mutagenesis; SITE-DIRECTED MUTAGENESIS; SATURATION MUTAGENESIS; LABORATORY EVOLUTION; THEORETICAL INVESTIGATIONS; DIHYDROFOLATE-REDUCTASE; COOPERATIVE MUTATIONS; SUBSTRATE-SPECIFICITY; FITNESS LANDSCAPE; LIBRARY DESIGN; BINDING-SITE;
D O I：
10.1002/anie.201207842
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Additive or non-additive, that is the question: The increasing awareness of non-additive cooperative mutational effects in protein engineering is currently providing new theoretical and practical insights. In particular, the directed evolution of stereoselective enzymes as catalysts in organic chemistry and biotechnology profits from this intriguing development. Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
引用
收藏
页码：2658 / 2666
页数：9
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