A novel fluorescent probe for selective detection of thiols in acidic solutions and labeling of acidic organelles in live cells

被引：22
|
作者：
Song, Qin-Hua [1 ]
Wu, Qing-Qing [1 ]
Liu, Chang-Hui [1 ]
Du, Xiao-Jiao [2 ]
Guo, Qing-Xiang [1 ]
机构：
[1] Univ Sci & Technol China, Joint Lab Green Synthet Chem, Dept Chem, Hefei 230026, Peoples R China
[2] Univ Sci & Technol China, Sch Life Sci, Hefei 230027, Peoples R China
来源：
JOURNAL OF MATERIALS CHEMISTRY B | 2013年 / 1卷 / 04期
基金：
中国国家自然科学基金;
关键词：
CYSTEINE; GLUTATHIONE; HOMOCYSTEINE;
D O I：
10.1039/c2tb00402j
中图分类号：
TB3 [工程材料学]; R318.08 [生物材料学];
学科分类号：
0805 ; 080501 ; 080502 ;
摘要：
A novel fluorescent probe, quinoline alpha,beta-unsaturated diacid (QMA), as compared to its ester QME, was constructed and can selectively detect thiols in acidic solutions (pH < 7) via a H-bond activated Michael addition. Furthermore, labeling of lysosomes and cell imaging were achieved by the detection of biothiols in different domains of live cells.
引用
收藏
页码：438 / 442
页数：5
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