Verbal learning in Alzheimer's disease and mild cognitive impairment: fine-grained acquisition and short-delay consolidation performance and neural correlates

被引：22

作者：

Genon, Sarah ^{[1
]}

Collette, Fabienne ^{[1
]}

Moulin, Chris J. A. ^{[2
]}

Lekeu, Francoise ^{[3
]}

Bahri, Mohamed Ali ^{[1
]}

Salmon, Eric ^{[1
,3
]}

Bastin, Christine ^{[1
]}

机构：

[1] Univ Liege, Cyclotron Res Ctr, B-4000 Liege, Belgium

[2] Univ Leeds, Leeds Memory Grp, Leeds, W Yorkshire, England

[3] CHU Liege, Memory Ctr, Liege, Belgium

来源：

NEUROBIOLOGY OF AGING | 2013年 / 34卷 / 02期

基金：

英国经济与社会研究理事会;

关键词：

Alzheimer's disease; Mild cognitive impairment; Verbal learning; Verbal acquisition; Short-delay consolidation; Brain imaging; FREE-RECALL PERFORMANCE; POSTEROVENTRAL PALLIDOTOMY; RELATIONAL MEMORY; HIPPOCAMPUS; DIAGNOSIS; RETENTION; RETRIEVAL; BRAIN; FMRI; MRI;

D O I：

10.1016/j.neurobiolaging.2012.04.004

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

The aim of this study was to examine correlations between acquisition and short-delay consolidation and brain metabolism at rest measured by fluorodeoxyglucose positron emission tomography (FDG-PET) in 44 Alzheimer's disease (AD) patients, 16 patients with mild cognitive impairment (MCI) who progressed to dementia (MCI-AD), 15 MCI patients who remained stable (MCI-S, 4-8 years of follow-up), and 20 healthy older participants. Acquisition and short-delay consolidation were calculated respectively as mean gained (MG) and lost (ML) access to items of the California Verbal Learning Task. MG performance suggests that acquisition is impaired in AD patients even at predementia stage (MCI-AD). ML performance suggests that short-delay consolidation is deficient only in confirmed AD patients. Variations in acquisition performance in control participants are related to metabolic activity in the anterior parietal cortex, an area supporting task-positive attentional processes. In contrast, the acquisition deficit is related to decreased activity in the lateral temporal cortex, an area supporting semantic processes, in patients at an early stage of AD and is related to metabolic activity in the hippocampus, an area supporting associative processes, in confirmed AD patients. (C) 2013 Elsevier Inc. All rights reserved.

引用

页码：361 / 373

页数：13

共 64 条

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